Interactor 1: CDC45 (O75419)
Cell division control protein 45 homolog (PORC-PI-1)
Gene: CDC45

Interactor 2: MCM3 (P25205)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
Gene: MCM3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.829

The method score is based on:

Property Details
Experiments 27621311, 12614612, 23364835
Identification Methods affinity chromatography technology, two hybrid
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains CDC45~MCM_lid, CDC45~MCM_N, CDC45~MCM_OB
Common GO terms GO:0000727 - double-strand break repair via break-induced replication
GO:0003697 - single-stranded DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005813 - centrosome
and 3 others

more...

Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 566
Hs

1 808
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Dm
+ Dm
+ Sp
+ Dm
+ Sp
+ Sc
+ Sc
+ Sc
+ Sp
+ Sc
+ Sc

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Last updated: 15 Jul 2024