HitPredict

Interactor 1: SRS10 (O75494)
Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
Gene: SRSF10

Interactor 2: TRA2B (P62995)
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
Gene: TRA2B

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.775

Property	Details
Experiments	24981860, 22365833
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000375 - RNA splicing, via transesterification reactions GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 262 Hs			1 288
+	Hs
		1040368 SRS12_HUMAN (1-251): 1.31e-38: 137: 46.33		TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06
+	Hs
		266984 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06
+	Hs
		1347098 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		RBM22_HUMAN (2-287): 6.71e-33: 126: 15.91
+	Hs
		925150 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00
+	Hs
		266976 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00
+	Hs
		925003 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00
+	Mm
		925159 SRSF3_MOUSE (1-95): 1.17e-25: 100: 35.79		TRA2B_MOUSE (1-267): 9.15e-34: 126: 100.00
+	Hs
		952152 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		RBM22_HUMAN (2-287): 6.71e-33: 126: 15.91
+	Hs
		266904 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		PABP1_HUMAN (109-246): 8.28e-22: 96.8: 21.99
+	Ce
		1353617 Q9U2S6_CAEEL (10-114): 3.55e-31: 119: 22.86		Q9U2S6_CAEEL (118-203): 1.61e-24: 102: 35.56
+	Hs
		1020353 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00
+	Hs
		266990 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Hs
		516744 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		PABP1_HUMAN (109-246): 8.28e-22: 96.8: 21.99
+	Hs
		1054669 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Hs
		951937 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		ELAV2_HUMAN (52-244): 6.85e-24: 101: 20.00
+	Hs
		516466 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		PABP1_HUMAN (109-246): 8.28e-22: 96.8: 21.99
+	Hs
		266989 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		HNRPD_HUMAN (106-178): 6.05e-11: 64: 26.03
+	Hs
		951964 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		RBM39_HUMAN (15-248): 3.58e-18: 86.1: 21.83
+	Hs
		680437 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		TIA1_HUMAN (113-248): 8.75e-18: 84.1: 18.42
+	Hs
		951962 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		CIRBP_HUMAN (120-192): 7.93e-11: 61.6: 57.53