HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.635

Property	Details
Experiments	16357870, 22094255
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 441 Hs			1 1616
+	Mm
		533918 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		DNMT1_MOUSE (1-1597): 0: 1615: 77.33
+	Hs
		641257 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		DNMT1_HUMAN (1-1616): 0: 1717: 100.00
+	Hs
		641180 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		DNMT1_HUMAN (1-1616): 0: 1717: 100.00
+	At
		713425 FIE_ARATH (42-268): 3.1e-14: 75.8: 9.52		DNMT1_ARATH (263-1604): 0: 964: 29.28
+	Hs
		268154 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		PB1_HUMAN (42-1162): 0: 602: 15.37
+	Mm
		101542 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		F8VQD1_MOUSE (42-1162): 0: 600: 14.69
+	Dm
		836164 TAF5_DROME (85-367): 9.54e-17: 84.8: 17.48		Q9VC36_DROME (243-1099): 4.48e-111: 391: 11.16
+	Hs
		268314 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		DNM3B_HUMAN (1130-1325): 2.44e-41: 167: 17.65
+	Mm
		1265474 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		SMC3_MOUSE (112-523): 3.81e-40: 165: 12.53
+	Hs
		268336 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		SMC3_HUMAN (112-523): 4.15e-40: 164: 12.53
+	Mm
		291751 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		DNM3B_MOUSE (1124-1325): 1.81e-39: 161: 18.52
+	Mm
		291737 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		DNM3A_MOUSE (1128-1326): 6.78e-37: 153: 17.87
+	Hs
		268353 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		DNM3A_HUMAN (1128-1326): 1.35e-36: 152: 17.87
+	Hs
		268238 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		MINT_HUMAN (5-706): 1.98e-35: 150: 12.71
+	Hs
		268143 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		NIPBL_HUMAN (4-361): 1.81e-13: 78.5: 14.14
+	Mm
		1154100 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		NIPBL_MOUSE (29-361): 1.06e-12: 75.8: 14.66
+	Hs
		1288258 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		MINT_HUMAN (5-706): 1.98e-35: 150: 12.71
+	Hs
		1302927 NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09		MINT_HUMAN (5-706): 1.98e-35: 150: 12.71