HitPredict

Interactor 1: KS6A5 (O75582)
Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL)
Gene: RPS6KA5

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.60	0.569

Property	Details
Experiments	17512525
Identification Methods	enzymatic study, protein kinase assay
Interaction Type	direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 802 Hs			1 758
+	Hs
		497071 KS6A1_HUMAN (4-752): 0: 714: 40.27		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		1057021 KS6A6_HUMAN (3-752): 0: 688: 39.55		MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57
+	Hs
		496604 KS6A3_HUMAN (366-776): 2.03e-107: 347: 23.47		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496408 AKT2_HUMAN (365-708): 1.8e-103: 329: 29.36		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496407 AKT1_HUMAN (375-708): 8.05e-98: 314: 26.14		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496248 KAPCA_HUMAN (422-737): 2.5e-99: 313: 27.66		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496317 KS6B1_HUMAN (393-797): 2.27e-94: 306: 22.92		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		503261 KAPCA_HUMAN (422-737): 2.5e-99: 313: 27.66		MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55
+	Hs
		152597 AKT1_HUMAN (375-708): 8.05e-98: 314: 26.14		KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55
+	Hs
		496492 KPCI_HUMAN (401-676): 1.59e-25: 114: 27.59		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00