HitPredict

Interactor 1: LRP5 (O75197)
Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)
Gene: LRP5

Interactor 2: DKK2 (Q9UBU2)
Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2)
Gene: DKK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DIKK1-2-4_C-subdom1~Ldl_recept_b, DIKK1-2-4_C-subdom2~Ldl_recept_b
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1615 Hs			1 259
+	Hs
		274845 LRP5_HUMAN (27-1615): 0: 1835: 100.00		DKK1_HUMAN (15-258): 1.13e-108: 316: 41.60
+	Hs
		274929 LRP5_HUMAN (27-1615): 0: 1835: 100.00		DKK4_HUMAN (78-259): 1.66e-78: 238: 43.55
+	Hs
		287625 LRP6_HUMAN (6-947): 0: 925: 38.67		DKK2_HUMAN (1-259): 6.54e-127: 362: 100.00
+	Hs
		287503 LRP6_HUMAN (6-947): 0: 925: 38.67		DKK1_HUMAN (15-258): 1.13e-108: 316: 41.60
+	Mm
		236652 LRP6_MOUSE (8-646): 3.65e-180: 585: 37.54		DKK1_MOUSE (12-258): 8.67e-114: 329: 42.80
+	Hs
		1366679 SORL_HUMAN (1182-1335): 4.02e-12: 73.9: 23.89		DKK2_HUMAN (1-259): 6.54e-127: 362: 100.00
+	Hs
		1022663 LRP2_HUMAN (1165-1374): 4.5e-09: 63.9: 12.05		DKK2_HUMAN (1-259): 6.54e-127: 362: 100.00
+	Hs
		1453579 LRP1B_HUMAN (1254-1402): 5.79e-09: 63.5: 24.54		DKK2_HUMAN (1-259): 6.54e-127: 362: 100.00