Protein: DKK2
Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2)

Gene: DKK2
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q9UBU2

Gene Ontology (top 5):
GO:0005615 - extracellular space
GO:0016055 - Wnt signaling pathway
GO:0039706 - co-receptor binding
GO:0048019 - receptor antagonist activity
GO:0090090 - negative regulation of canonical Wnt signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

287625

LRP6
Low-density lipoprotein receptor-related protein 6

2

8

Small-scale

0.799

High

1366679

SORL
Sortilin-related receptor

1

8

High-throughput

0.691

High

274930

LRP5
Low-density lipoprotein receptor-related protein 5

1

8

High-throughput

0.618

High

1022663

LRP2
Low-density lipoprotein receptor-related protein 2

1

8

High-throughput

0.618

High

1453579

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

9

High-throughput

0.618

High

950213

KR106
Keratin-associated protein 10-6

2

1

High-throughput

0.553

High

445086

S10A9
Protein S100-A9

1

1

High-throughput

0.536

High

713478

SPB3
Serpin B3

1

1

High-throughput

0.536

High

724647

S10A7
Protein S100-A7

1

1

High-throughput

0.536

High

874881

SPB4
Serpin B4

1

1

High-throughput

0.536

High

999422

HBB
Hemoglobin subunit beta

1

1

High-throughput

0.536

High

999698

HBA
Hemoglobin subunit alpha

1

1

High-throughput

0.536

High

390963

TRFE
Serotransferrin

1

0

High-throughput

0.513

High

458024

TRY2
Trypsin-2

1

0

High-throughput

0.513

High

568183

PLSL
Plastin-2

1

0

High-throughput

0.513

High

857578

NOTC1
Neurogenic locus notch homolog protein 1

1

0

High-throughput

0.513

High

868786

LEG7
Galectin-7

1

0

High-throughput

0.513

High

1009739

NGAL
Neutrophil gelatinase-associated lipocalin

1

0

High-throughput

0.513

High

1353675

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.513

High

207888

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

1

High-throughput

0.489

High

230128

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

1

High-throughput

0.489

High

380372

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

1

High-throughput

0.489

High

711795

ARI4A
AT-rich interactive domain-containing protein 4A

1

1

High-throughput

0.489

High

1195610

ARI4B
AT-rich interactive domain-containing protein 4B

1

1

High-throughput

0.489

High

1208650

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

2

High-throughput

0.489

High

1212623

HECD3
E3 ubiquitin-protein ligase HECTD3

1

1

High-throughput

0.489

High

1393329

SAHH3
Adenosylhomocysteinase 3

1

1

High-throughput

0.489

High

1435864

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

2

High-throughput

0.489

High

1439493

BRMS1
Breast cancer metastasis-suppressor 1

1

2

High-throughput

0.489

High

380493

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

1

High-throughput

0.437

High

379406

IGHG2
Immunoglobulin heavy constant gamma 2

1

0

High-throughput

0.426

High

282324

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.279

Low

451583

CENPB
Major centromere autoantigen B

1

0

High-throughput

0.279

Low

457930

INVO
Involucrin

1

0

High-throughput

0.279

Low

475044

VIME
Vimentin

1

0

High-throughput

0.279

Low

568986

ANXA8
Annexin A8

1

0

High-throughput

0.279

Low

652431

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.279

Low

720895

KPYR
Pyruvate kinase PKLR

1

0

High-throughput

0.279

Low

1286479

DSG4
Desmoglein-4

1

0

High-throughput

0.279

Low

1307265

TF2LX
Homeobox protein TGIF2LX

1

0

High-throughput

0.279

Low

1388020

RSPRY
RING finger and SPRY domain-containing protein 1

1

0

High-throughput

0.279

Low

1403038

SIN3A
Paired amphipathic helix protein Sin3a

1

0

High-throughput

0.279

Low

1413852

DHRS4
Dehydrogenase/reductase SDR family member 4

1

0

High-throughput

0.279

Low

1429914

SP130
Histone deacetylase complex subunit SAP130

1

0

High-throughput

0.279

Low

1458727

ING1
Inhibitor of growth protein 1

1

0

High-throughput

0.279

Low

1458728

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.279

Low

783442

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

High-throughput

0.249

Low

516729

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025