HitPredict

Interactor 1: PROP1 (O75360)
Homeobox protein prophet of Pit-1 (PROP-1) (Pituitary-specific homeodomain factor)
Gene: PROP1

Interactor 2: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20181723
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005667 - transcription regulator complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 226 Hs			1 770
+	Hs
		662215 PAX7_HUMAN (52-223): 3.27e-32: 123: 28.02		TLE1_HUMAN (1-770): 0: 600: 100.00
+	Hs
		685162 PAX6_HUMAN (23-226): 6.54e-31: 119: 25.47		TLE1_HUMAN (1-770): 0: 600: 100.00
+	Hs
		1047836 LHX8_HUMAN (47-200): 1.55e-30: 117: 26.62		TLE1_HUMAN (1-770): 0: 600: 100.00
+	Hs
		1047831 ISX_HUMAN (1-213): 5.41e-31: 115: 23.77		TLE1_HUMAN (1-770): 0: 600: 100.00
+	Hs
		662217 PAX7_HUMAN (52-223): 3.27e-32: 123: 28.02		TLE4_HUMAN (1-770): 0: 571: 86.53
+	Mm
		666052 PAX3_MOUSE (10-224): 4.68e-30: 117: 23.72		TLE4_MOUSE (1-770): 0: 573: 86.53
+	Hs
		685164 PAX6_HUMAN (23-226): 6.54e-31: 119: 25.47		TLE4_HUMAN (1-770): 0: 571: 86.53
+	Hs
		662216 PAX7_HUMAN (52-223): 3.27e-32: 123: 28.02		TLE3_HUMAN (1-770): 1.2e-180: 537: 77.29
+	Hs
		685163 PAX6_HUMAN (23-226): 6.54e-31: 119: 25.47		TLE3_HUMAN (1-770): 1.2e-180: 537: 77.29
+	Hs
		277093 PROP1_HUMAN (1-226): 4.2e-38: 133: 100.00		TLE5_HUMAN (1-200): 4.92e-91: 285: 64.50
+	Hs
		662219 PAX7_HUMAN (52-223): 3.27e-32: 123: 28.02		TLE5_HUMAN (1-200): 4.92e-91: 285: 64.50
+	Hs
		685170 PAX6_HUMAN (23-226): 6.54e-31: 119: 25.47		TLE5_HUMAN (1-200): 4.92e-91: 285: 64.50
+	Ce
		146025 UNC4_CAEEL (15-213): 9.83e-35: 125: 25.63		UNC37_CAEEL (18-684): 7.07e-79: 267: 18.91
+	Hs
		261365 PAX7_HUMAN (52-223): 3.27e-32: 123: 28.02		TBL1X_HUMAN (351-729): 3.13e-75: 256: 12.84
+	Hs
		261369 PAX6_HUMAN (23-226): 6.54e-31: 119: 25.47		TBL1X_HUMAN (351-729): 3.13e-75: 256: 12.84
+	Mm
		1490157 MIXL1_MOUSE (16-170): 1.08e-36: 130: 36.97		TLE6_MOUSE (471-770): 9.17e-46: 174: 33.99
+	Mm
		204354 ALX4_MOUSE (13-209): 1.15e-32: 123: 25.89		TLE6_MOUSE (471-770): 9.17e-46: 174: 33.99
+	Mm
		724909 HXA2_MOUSE (4-223): 1.08e-30: 118: 17.33		TLE6_MOUSE (471-770): 9.17e-46: 174: 33.99
+	Hs
		662211 PAX7_HUMAN (52-223): 3.27e-32: 123: 28.02		WDR5_HUMAN (233-558): 2.3e-23: 103: 9.88
+	Mm
		866404 PAX7_MOUSE (52-223): 3.86e-32: 123: 28.02		WDR5_MOUSE (233-558): 2.3e-23: 103: 9.88