HitPredict

Interactor 1: FLNB (O75369)
Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)
Gene: FLNB

Interactor 2: BCAR1 (P56945)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
Gene: BCAR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	28007913
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0015629 - actin cytoskeleton GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 2602 Hs			1 870
+	Hs
		278086 FLNB_HUMAN (1-2602): 0: 2855: 100.00		MDC1_HUMAN (56-759): 1.44e-20: 100: 8.77
+	Hs
		637747 FLNA_HUMAN (1-2602): 0: 2661: 69.59		CASS4_HUMAN (4-865): 7.52e-38: 154: 19.79
+	Hs
		637516 FLNA_HUMAN (1-2602): 0: 2661: 69.59		MDC1_HUMAN (56-759): 1.44e-20: 100: 8.77
+	Hs
		637660 FLNA_HUMAN (1-2602): 0: 2661: 69.59		TITIN_HUMAN (56-404): 7.29e-09: 62.1: 14.93
+	Hs
		555650 ACTN1_HUMAN (5-364): 3.9e-117: 397: 27.15		BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00
+	Hs
		942558 SPTB2_HUMAN (6-367): 4.88e-108: 389: 28.65		BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00
+	Mm
		236902 SPTB2_MOUSE (6-367): 4.87e-108: 389: 28.65		ACK1_MOUSE (9-581): 2.89e-29: 127: 13.93
+	Hs
		942960 MACF1_HUMAN (16-239): 9.34e-35: 149: 40.69		BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00
+	Hs
		1028778 SPTB2_HUMAN (6-367): 4.88e-108: 389: 28.65		ITSN1_HUMAN (2-173): 5.21e-24: 111: 23.16
+	Hs
		1061541 ACTN3_HUMAN (5-364): 1.22e-118: 402: 26.88		TITIN_HUMAN (56-404): 7.29e-09: 62.1: 14.93
+	Hs
		555729 ACTN1_HUMAN (5-364): 3.9e-117: 397: 27.15		TITIN_HUMAN (56-404): 7.29e-09: 62.1: 14.93
+	Hs
		773767 ACTN2_HUMAN (5-364): 2.61e-116: 395: 26.61		TITIN_HUMAN (56-404): 7.29e-09: 62.1: 14.93
+	Hs
		224763 ACTN4_HUMAN (12-364): 1e-113: 388: 26.58		TITIN_HUMAN (56-404): 7.29e-09: 62.1: 14.93
+	Hs
		1462480 MACF1_HUMAN (16-239): 9.34e-35: 149: 40.69		MACF1_HUMAN (505-867): 2.95e-74: 268: 13.79
+	Hs
		1040405 MACF1_HUMAN (16-239): 9.34e-35: 149: 40.69		DYST_HUMAN (457-866): 1.24e-66: 245: 12.07
+	Dm
		1472928 FLNA_DROME (2172-2601): 1.61e-61: 237: 26.01		Q9VLS7_DROME (113-735): 7.36e-11: 68.4: 9.35