HitPredict

Interactor 1: SC22B (O75396)
Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1)
Gene: SEC22B

Interactor 2: VAMP5 (O95183)
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Gene: VAMP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	30833792
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Longin~Synaptobrevin, Synaptobrevin~Synaptobrevin
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 116
+	Dm
		305566 O77434_DROME (1-215): 1.02e-77: 233: 56.74		Q7JYX5_DROME (4-96): 8e-33: 115: 31.18
+	Dm
		121797 M9PGI6_DROME (1-215): 5.4e-76: 229: 56.22		Q7JYX5_DROME (4-96): 8e-33: 115: 31.18
+	Dm
		305552 O77434_DROME (1-215): 1.02e-77: 233: 56.74		SYB_DROME (2-88): 1.37e-29: 105: 39.08
+	Dm
		121784 M9PGI6_DROME (1-215): 5.4e-76: 229: 56.22		SYB_DROME (2-88): 1.37e-29: 105: 39.08
+	Dm
		305601 O77434_DROME (1-215): 1.02e-77: 233: 56.74		NSYB_DROME (2-84): 8.87e-27: 99.2: 38.55
+	Hs
		328647 VAMP7_HUMAN (31-198): 2.72e-62: 195: 22.62		VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00
+	Dm
		614910 Q7JYX5_DROME (30-214): 6.09e-64: 199: 20.54		SYB_DROME (2-88): 1.37e-29: 105: 39.08
+	Sc
		646227 SEC22_YEAST (1-215): 3.09e-66: 204: 35.65		SNC2_YEAST (2-73): 1.07e-23: 89.6: 23.61
+	Sc
		646277 SEC22_YEAST (1-215): 3.09e-66: 204: 35.65		NYV1_YEAST (9-88): 1.29e-21: 87.6: 20.00
+	Hs
		907983 VAMP7_HUMAN (31-198): 2.72e-62: 195: 22.62		VAMP7_HUMAN (4-96): 3.28e-25: 96.1: 31.18
+	Hs
		192155 YKT6_HUMAN (30-188): 3.42e-53: 170: 23.13		VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00
+	Hs
		908012 VAMP7_HUMAN (31-198): 2.72e-62: 195: 22.62		VAMP3_HUMAN (2-72): 1.48e-24: 91.1: 38.03
+	Dm
		1263482 Q9W3M8_DROME (28-188): 3.54e-45: 150: 20.25		Q7JYX5_DROME (4-96): 8e-33: 115: 31.18
+	Dm
		614978 Q9W3M8_DROME (28-188): 3.54e-45: 150: 20.25		SYB_DROME (2-88): 1.37e-29: 105: 39.08
+	Sc
		779523 YKT6_YEAST (31-188): 1.81e-44: 148: 24.54		NYV1_YEAST (9-88): 1.29e-21: 87.6: 20.00