HitPredict

Interactor 1: DAB1 (O75553)
Disabled homolog 1
Gene: DAB1

Interactor 2: LDLR (P01130)
Low-density lipoprotein receptor (LDL receptor)
Gene: LDLR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	10827173, 9837937
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 588 Hs			1 860
+	Hs
		376509 ARH_HUMAN (1-243): 1.04e-46: 168: 19.69		LDLR_HUMAN (1-860): 0: 692: 100.00
+	Hs
		376496 DAB2_HUMAN (8-587): 2.76e-41: 161: 23.98		LDLR_HUMAN (1-860): 0: 692: 100.00
+	Mm
		778027 DAB1_MOUSE (1-588): 3.87e-74: 249: 91.50		LDLR_MOUSE (3-313): 4.41e-34: 142: 32.52
+	Mm
		73127 DAB1_MOUSE (1-588): 3.87e-74: 249: 91.50		B1AXJ3_MOUSE (18-270): 1.38e-31: 134: 26.04
+	Hs
		286368 DAB1_HUMAN (1-588): 2.32e-74: 250: 100.00		LRP8_HUMAN (189-645): 1.04e-23: 109: 18.57
+	Hs
		286356 DAB1_HUMAN (1-588): 2.32e-74: 250: 100.00		VLDLR_HUMAN (187-417): 1.44e-15: 83.3: 21.07
+	Mm
		1021148 DAB1_MOUSE (1-588): 3.87e-74: 249: 91.50		VLDLR_MOUSE (187-417): 8.21e-15: 81: 20.36
+	Mm
		1021160 DAB1_MOUSE (1-588): 3.87e-74: 249: 91.50		LRP8_MOUSE (185-389): 1.92e-14: 79.8: 24.64
+	Mm
		59780 DAB1_MOUSE (1-588): 3.87e-74: 249: 91.50		LRP2_MOUSE (230-467): 1.46e-09: 64.4: 18.22
+	Hs
		286357 DAB1_HUMAN (1-588): 2.32e-74: 250: 100.00		LRP2_HUMAN (218-420): 6.15e-09: 62.1: 21.23
+	Hs
		286364 DAB1_HUMAN (1-588): 2.32e-74: 250: 100.00		LRP1_HUMAN (24-203): 6.74e-09: 62.1: 23.37
+	Mm
		1021159 DAB1_MOUSE (1-588): 3.87e-74: 249: 91.50		LRP1_MOUSE (24-203): 7.65e-09: 62.1: 24.46
+	Hs
		1060927 GULP1_HUMAN (17-293): 2.74e-60: 204: 21.43		LRP1_HUMAN (24-203): 6.74e-09: 62.1: 23.37
+	Rn
		313033 DAB2_RAT (8-587): 1.43e-43: 168: 22.92		LRP2_RAT (195-424): 3.59e-13: 76: 23.77
+	Hs
		1022627 ANS1B_HUMAN (9-229): 2.09e-44: 171: 17.70		LRP2_HUMAN (218-420): 6.15e-09: 62.1: 21.23
+	Hs
		1060889 ANS1B_HUMAN (9-229): 2.09e-44: 171: 17.70		LRP1_HUMAN (24-203): 6.74e-09: 62.1: 23.37
+	Mm
		59781 DAB2_MOUSE (8-587): 1.15e-43: 168: 23.51		LRP2_MOUSE (230-467): 1.46e-09: 64.4: 18.22
+	Hs
		287552 DAB2_HUMAN (8-587): 2.76e-41: 161: 23.98		LRP6_HUMAN (194-349): 3.8e-11: 69.4: 27.44
+	Hs
		1022618 ARH_HUMAN (1-243): 1.04e-46: 168: 19.69		LRP2_HUMAN (218-420): 6.15e-09: 62.1: 21.23
+	Hs
		1022147 DAB2_HUMAN (8-587): 2.76e-41: 161: 23.98		LRP2_HUMAN (218-420): 6.15e-09: 62.1: 21.23