HitPredict

Interactor 1: LRP2 (A2ARV4)
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
Gene: LRP2

Interactor 2: DAB1 (P97318)
Disabled homolog 1 (mDab1)
Gene: DAB1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.42	0.50	0.462

Property	Details
Experiments	10827173
Identification Methods	two hybrid, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4660 Mm			1 588
+	Hs
		286357 LRP2_HUMAN (1-4660): 0: 3732: 76.64		DAB1_HUMAN (1-588): 1.28e-78: 261: 91.50
+	Rn
		313033 LRP2_RAT (1-4660): 0: 3826: 93.88		DAB2_RAT (8-587): 8.2e-41: 160: 25.34
+	Mm
		59785 LRP2_MOUSE (1-4660): 0: 3817: 100.00		ARH_MOUSE (8-271): 5.78e-45: 163: 16.67
+	Rn
		92834 LRP2_RAT (1-4660): 0: 3826: 93.88		ARH_RAT (8-271): 6.71e-42: 154: 16.30
+	Mm
		59781 LRP2_MOUSE (1-4660): 0: 3817: 100.00		DAB2_MOUSE (8-587): 2.67e-40: 158: 25.71
+	Hs
		1022618 LRP2_HUMAN (1-4660): 0: 3732: 76.64		ARH_HUMAN (11-271): 2.48e-48: 172: 18.35
+	Hs
		1022627 LRP2_HUMAN (1-4660): 0: 3732: 76.64		ANS1B_HUMAN (8-229): 3.5e-44: 171: 16.81
+	Hs
		1022147 LRP2_HUMAN (1-4660): 0: 3732: 76.64		DAB2_HUMAN (8-584): 2.29e-39: 155: 25.47
+	Hs
		269758 LRP2_HUMAN (1-4660): 0: 3732: 76.64		CAPON_HUMAN (11-299): 2.5e-36: 144: 15.11
+	Mm
		1021148 VLDLR_MOUSE (183-468): 4.28e-19: 98: 22.95		DAB1_MOUSE (1-588): 2.09e-86: 281: 100.00
+	Mm
		778027 LDLR_MOUSE (926-1243): 2.14e-14: 82.6: 19.12		DAB1_MOUSE (1-588): 2.09e-86: 281: 100.00
+	Mm
		73127 B1AXJ3_MOUSE (3435-3650): 4.79e-10: 68.3: 16.37		DAB1_MOUSE (1-588): 2.09e-86: 281: 100.00
+	Hs
		286337 LDLR_HUMAN (2603-2890): 7.51e-16: 87.2: 19.24		DAB1_HUMAN (1-588): 1.28e-78: 261: 91.50
+	Mm
		1021159 LRP1_MOUSE (3784-4047): 4.34e-09: 65.6: 13.43		DAB1_MOUSE (1-588): 2.09e-86: 281: 100.00
+	Mm
		1021160 LRP8_MOUSE (1-137): 3.19e-09: 65.6: 19.29		DAB1_MOUSE (1-588): 2.09e-86: 281: 100.00
+	Hs
		286356 VLDLR_HUMAN (920-1171): 9.67e-14: 80.3: 18.58		DAB1_HUMAN (1-588): 1.28e-78: 261: 91.50
+	Hs
		376509 LDLR_HUMAN (2603-2890): 7.51e-16: 87.2: 19.24		ARH_HUMAN (11-271): 2.48e-48: 172: 18.35
+	Hs
		376496 LDLR_HUMAN (2603-2890): 7.51e-16: 87.2: 19.24		DAB2_HUMAN (8-584): 2.29e-39: 155: 25.47
+	Hs
		287552 LRP6_HUMAN (2836-2990): 8.46e-10: 67.9: 28.40		DAB2_HUMAN (8-584): 2.29e-39: 155: 25.47
+	Ce
		63398 LRP_CAEEL (220-617): 7.76e-10: 67.9: 16.46		A5JYR4_CAEEL (2-386): 1.91e-36: 144: 23.06