HitPredict

Interactor 1: DAB1 (O75553)
Disabled homolog 1
Gene: DAB1

Interactor 2: APLP1 (P51693)
Amyloid beta precursor like protein 1 (Amyloid beta (A4) precursor-like protein 1) (Amyloid-like protein 1) (APLP) (APLP-1) [Cleaved into: C30]
Gene: APLP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	10460257
Identification Methods	pull down, affinity chromatography technology, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	APP_amyloid~PID
Common GO terms	GO:0007409 - axonogenesis GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 588 Hs			1 650
+	Mm
		1021150 DAB1_MOUSE (1-588): 3.87e-74: 249: 91.50		APLP1_MOUSE (1-650): 0: 852: 88.38
+	Mm
		1021152 DAB1_MOUSE (1-588): 3.87e-74: 249: 91.50		APLP2_MOUSE (42-648): 0: 843: 39.82
+	Hs
		286363 DAB1_HUMAN (1-588): 2.32e-74: 250: 100.00		APLP2_HUMAN (42-648): 0: 822: 35.25
+	Hs
		907306 DAB2_HUMAN (8-587): 2.76e-41: 161: 23.98		APLP1_HUMAN (1-650): 0: 906: 100.00
+	Hs
		1022151 DAB2_HUMAN (8-587): 2.76e-41: 161: 23.98		APLP2_HUMAN (42-648): 0: 822: 35.25
+	Mm
		551414 DAB1_MOUSE (1-588): 3.87e-74: 249: 91.50		A4_MOUSE (23-241): 1.65e-115: 364: 42.27
+	Hs
		286341 DAB1_HUMAN (1-588): 2.32e-74: 250: 100.00		A4_HUMAN (41-243): 2.2e-109: 349: 42.16
+	Mm
		551511 NUMB_MOUSE (4-549): 1.35e-48: 181: 15.59		A4_MOUSE (23-241): 1.65e-115: 364: 42.27
+	Mm
		551417 DAB2_MOUSE (8-587): 1.15e-43: 168: 23.51		A4_MOUSE (23-241): 1.65e-115: 364: 42.27
+	Hs
		421724 NUMB_HUMAN (4-549): 1.7e-46: 175: 15.64		A4_HUMAN (41-243): 2.2e-109: 349: 42.16
+	Hs
		422447 ANS1B_HUMAN (9-229): 2.09e-44: 171: 17.70		A4_HUMAN (41-243): 2.2e-109: 349: 42.16
+	Hs
		422281 ARH_HUMAN (1-243): 1.04e-46: 168: 19.69		A4_HUMAN (41-243): 2.2e-109: 349: 42.16
+	Hs
		421923 DAB2_HUMAN (8-587): 2.76e-41: 161: 23.98		A4_HUMAN (41-243): 2.2e-109: 349: 42.16
+	Mm
		551436 SHC3_MOUSE (10-351): 7.08e-37: 145: 16.06		A4_MOUSE (23-241): 1.65e-115: 364: 42.27
+	Hs
		269726 CAPON_HUMAN (11-325): 9.87e-36: 142: 14.37		A4_HUMAN (41-243): 2.2e-109: 349: 42.16
+	Hs
		422748 SHC3_HUMAN (10-354): 2.25e-35: 142: 16.53		A4_HUMAN (41-243): 2.2e-109: 349: 42.16