HitPredict

Interactor 1: APLP1 (P51693)
Amyloid beta precursor like protein 1 (Amyloid beta (A4) precursor-like protein 1) (Amyloid-like protein 1) (APLP) (APLP-1) [Cleaved into: C30]
Gene: APLP1

Interactor 2: DAB2 (P98082)
Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)
Gene: DAB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11247302
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	APP_amyloid~PID
Common GO terms	GO:0005886 - plasma membrane GO:0006915 - apoptotic process GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 650 Hs			1 770
+	Hs
		1022151 APLP2_HUMAN (42-648): 0: 822: 35.25		DAB2_HUMAN (1-770): 1.93e-88: 297: 100.00
+	Hs
		286350 APLP1_HUMAN (1-650): 0: 906: 100.00		DAB1_HUMAN (16-597): 9.98e-41: 160: 23.39
+	Mm
		1021150 APLP1_MOUSE (1-650): 0: 852: 88.38		DAB1_MOUSE (16-597): 4.37e-41: 161: 24.07
+	Mm
		1021152 APLP2_MOUSE (42-648): 0: 843: 39.82		DAB1_MOUSE (16-597): 4.37e-41: 161: 24.07
+	Hs
		286363 APLP2_HUMAN (42-648): 0: 822: 35.25		DAB1_HUMAN (16-597): 9.98e-41: 160: 23.39
+	Mm
		551417 A4_MOUSE (23-241): 1.65e-115: 364: 42.27		DAB2_MOUSE (1-770): 1.13e-83: 284: 82.15
+	Hs
		421923 A4_HUMAN (41-243): 2.2e-109: 349: 42.16		DAB2_HUMAN (1-770): 1.93e-88: 297: 100.00
+	Mm
		551511 A4_MOUSE (23-241): 1.65e-115: 364: 42.27		NUMB_MOUSE (21-658): 4.93e-48: 182: 13.73
+	Hs
		421724 A4_HUMAN (41-243): 2.2e-109: 349: 42.16		NUMB_HUMAN (21-639): 1.06e-49: 187: 13.78
+	Hs
		422281 A4_HUMAN (41-243): 2.2e-109: 349: 42.16		ARH_HUMAN (3-275): 4.94e-50: 179: 13.13
+	Mm
		551414 A4_MOUSE (23-241): 1.65e-115: 364: 42.27		DAB1_MOUSE (16-597): 4.37e-41: 161: 24.07
+	Hs
		422447 A4_HUMAN (41-243): 2.2e-109: 349: 42.16		ANS1B_HUMAN (12-224): 1.23e-40: 163: 19.27
+	Hs
		286341 A4_HUMAN (41-243): 2.2e-109: 349: 42.16		DAB1_HUMAN (16-597): 9.98e-41: 160: 23.39
+	Hs
		269726 A4_HUMAN (41-243): 2.2e-109: 349: 42.16		CAPON_HUMAN (19-301): 2.54e-35: 142: 12.87
+	Hs
		421441 A4_HUMAN (41-243): 2.2e-109: 349: 42.16		MUC1_HUMAN (329-768): 5.91e-15: 81.5: 9.25