HitPredict

Interactor 1: SKAP2 (O75563)
Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains)
Gene: SKAP2

Interactor 2: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	29568343
Identification Methods	protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1, PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 359 Hs			1 543
+	Hs
		286757 SKAP2_HUMAN (1-359): 7.68e-120: 352: 100.00		SRC_HUMAN (1-543): 0: 602: 74.22
+	Mm
		813517 SKAP2_MOUSE (1-359): 2.7e-120: 353: 90.53		FYN_MOUSE (1-543): 0: 584: 71.98
+	Hs
		286751 SKAP2_HUMAN (1-359): 7.68e-120: 352: 100.00		FYN_HUMAN (1-543): 0: 584: 72.16
+	Hs
		286755 SKAP2_HUMAN (1-359): 7.68e-120: 352: 100.00		FGR_HUMAN (1-542): 0: 564: 67.10
+	Hs
		463146 SKAP1_HUMAN (13-359): 1.43e-97: 295: 42.54		YES_HUMAN (1-543): 0: 618: 100.00
+	Hs
		286754 SKAP2_HUMAN (1-359): 7.68e-120: 352: 100.00		HCK_HUMAN (1-541): 0: 545: 57.49
+	Mm
		440280 SKAP2_MOUSE (1-359): 2.7e-120: 353: 90.53		LCK_MOUSE (83-541): 0: 544: 60.78
+	Hs
		557366 SKAP1_HUMAN (13-359): 1.43e-97: 295: 42.54		SRC_HUMAN (1-543): 0: 602: 74.22
+	Hs
		286750 SKAP2_HUMAN (1-359): 7.68e-120: 352: 100.00		LCK_HUMAN (83-541): 0: 542: 60.78
+	Hs
		440618 SKAP1_HUMAN (13-359): 1.43e-97: 295: 42.54		FYN_HUMAN (1-543): 0: 584: 72.16
+	Mm
		683096 SKAP2_MOUSE (1-359): 2.7e-120: 353: 90.53		LYN_MOUSE (1-541): 2.87e-180: 519: 53.14
+	Hs
		286753 SKAP2_HUMAN (1-359): 7.68e-120: 352: 100.00		LYN_HUMAN (1-541): 9.2e-180: 517: 53.69
+	Hs
		286765 SKAP2_HUMAN (1-359): 7.68e-120: 352: 100.00		BLK_HUMAN (66-541): 1.31e-174: 504: 58.70
+	Hs
		286761 SKAP2_HUMAN (1-359): 7.68e-120: 352: 100.00		FRK_HUMAN (71-535): 2.12e-172: 498: 48.25
+	Hs
		440135 SKAP1_HUMAN (13-359): 1.43e-97: 295: 42.54		LCK_HUMAN (83-541): 0: 542: 60.78
+	Hs
		286787 SKAP2_HUMAN (1-359): 7.68e-120: 352: 100.00		SRMS_HUMAN (61-534): 1.14e-163: 475: 39.20
+	Hs
		463624 SKAP1_HUMAN (13-359): 1.43e-97: 295: 42.54		LYN_HUMAN (1-541): 9.2e-180: 517: 53.69
+	Hs
		463129 PKHA7_HUMAN (26-316): 4.44e-42: 158: 14.52		YES_HUMAN (1-543): 0: 618: 100.00
+	Hs
		440118 PKHA7_HUMAN (26-316): 4.44e-42: 158: 14.52		LCK_HUMAN (83-541): 0: 542: 60.78
+	Hs
		463588 PKHA7_HUMAN (26-316): 4.44e-42: 158: 14.52		LYN_HUMAN (1-541): 9.2e-180: 517: 53.69