Interactor 1: SLIT2 (O94813)
Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product]
Gene: SLIT2

Interactor 2: ROBO1 (Q9Y6N7)
Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1)
Gene: ROBO1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.47 1.00 0.692

The method score is based on:

Property Details
Experiments 17848514
Identification Methods surface plasmon resonance, x-ray crystallography
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Ig_3~Laminin_G_1, I-set~LRR_8, Ig_3~LRR_8
Common GO terms GO:0002042 - cell migration involved in sprouting angiogenesis
GO:0003180 - aortic valve morphogenesis
GO:0003184 - pulmonary valve morphogenesis
GO:0005737 - cytoplasm
GO:0021836 - chemorepulsion involved in postnatal olfactory bulb interneuron migration
and 5 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 1529
Hs

1 1651
+ Dr
+ Dr
+ Ce
+ Mm
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm
+ Hs
+ Hs
+ Dr
+ Dm
+ Dm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024