Protein: ALDH5
Aldehyde dehydrogenase 5, mitochondrial (EC 1.2.1.-) (EC 1.2.1.4)

Gene: ALDH5, ALD5
Organism: Saccharomyces cerevisiae S288C
Interactions: 74
UniProt ID: P40047

Gene Ontology (top 5):
GO:0004029 - aldehyde dehydrogenase (NAD+) activity
GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006068 - ethanol catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

510529

HSP77
Import motor subunit, mitochondrial

3

5

High-throughput

0.633

High

817496

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

15

High-throughput

0.618

High

817495

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

5

High-throughput

0.584

High

526799

HSP72
Heat shock protein SSA2

2

9

High-throughput

0.552

High

448453

RAD52
DNA repair and recombination protein RAD52

1

1

High-throughput

0.536

High

594390

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

2

Small-scale

0.533

High

707209

TF2B
Transcription initiation factor IIB

2

3

High-throughput

0.526

High

817513

RUVB2
RuvB-like protein 2

2

3

High-throughput

0.521

High

367037

ATPB
ATP synthase subunit beta, mitochondrial

1

3

High-throughput

0.479

High

368169

THDH
Threonine dehydratase, mitochondrial

1

3

High-throughput

0.479

High

452665

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

2

High-throughput

0.479

High

456408

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

2

High-throughput

0.479

High

594951

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

4

High-throughput

0.479

High

604952

MDHM
Malate dehydrogenase, mitochondrial

1

3

High-throughput

0.479

High

622368

ACON
Aconitate hydratase, mitochondrial

1

3

High-throughput

0.479

High

635963

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

6

High-throughput

0.479

High

642142

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

1

High-throughput

0.479

High

654603

AIM17
Probable oxidoreductase AIM17

1

1

High-throughput

0.479

High

673508

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

3

High-throughput

0.479

High

685103

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

1

High-throughput

0.479

High

694471

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

1

High-throughput

0.479

High

701531

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

3

High-throughput

0.479

High

746993

PREP
Presequence protease, mitochondrial

1

4

High-throughput

0.479

High

752307

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.479

High

763441

MDJ1
DnaJ homolog 1, mitochondrial

1

3

High-throughput

0.479

High

781386

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.479

High

815129

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

817492

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

1

High-throughput

0.479

High

817494

ETFB
Probable electron transfer flavoprotein subunit beta

1

1

High-throughput

0.479

High

817499

ALAT1
Alanine aminotransferase, mitochondrial

1

2

High-throughput

0.479

High

817506

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

1

High-throughput

0.479

High

817507

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

15

High-throughput

0.479

High

817508

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

2

Small-scale

0.479

High

439139

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.458

High

484765

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

677808

ILV6
Acetolactate synthase small subunit, mitochondrial

1

0

High-throughput

0.458

High

737460

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.458

High

812189

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.458

High

817502

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

817510

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.458

High

817511

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

394599

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

453620

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.445

High

626755

HSP60
Heat shock protein 60, mitochondrial

1

4

High-throughput

0.445

High

558743

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.437

High

670760

SIS1
Protein SIS1

1

4

High-throughput

0.437

High

689047

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.437

High

737869

HOG1
Mitogen-activated protein kinase HOG1

1

2

High-throughput

0.437

High

750675

PRS6A
26S proteasome regulatory subunit 6A

1

6

High-throughput

0.437

High

779948

DOA1
Protein DOA1

1

4

Small-scale

0.437

High

795004

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

812336

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

817498

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

817501

HST2
NAD-dependent protein deacetylase HST2

1

7

High-throughput

0.437

High

817503

VPS60
Vacuolar protein-sorting-associated protein 60

1

1

Small-scale

0.437

High

817505

RUVB1
RuvB-like protein 1

1

3

High-throughput

0.437

High

817512

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.437

High

590638

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

386724

TBB
Tubulin beta chain

1

3

High-throughput

0.407

High

486195

TBA1
Tubulin alpha-1 chain

1

5

High-throughput

0.407

High

524076

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.407

High

545024

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.407

High

741663

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.407

High

817493

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.407

High

817497

PFD1
Prefoldin subunit 1

1

2

High-throughput

0.407

High

510969

IPB2
Protease B inhibitor 2

1

0

High-throughput

0.249

Low

739647

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

817490

TM108
Protein TMA108

1

0

High-throughput

0.249

Low

817491

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.249

Low

817500

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

817504

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.249

Low

817509

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.249

Low

743913

GDA1
Guanosine-diphosphatase

1

0

High-throughput

0.238

Low

811093

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025