HitPredict

Interactor 1: KLH18 (O94889)
Kelch-like protein 18
Gene: KLHL18

Interactor 2: CSN3 (Q9UNS2)
COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3)
Gene: COPS3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	33961781, 19295130
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 574 Hs			1 423
+	Hs
		1350341 KLHL8_HUMAN (3-572): 6.73e-160: 472: 34.90		CSN3_HUMAN (1-423): 2.33e-144: 419: 100.00
+	Hs
		1153800 KLH10_HUMAN (26-573): 1.28e-155: 460: 31.03		CSN3_HUMAN (1-423): 2.33e-144: 419: 100.00
+	Hs
		299512 KLH18_HUMAN (1-574): 9.48e-176: 510: 100.00		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	Hs
		897321 KLHL8_HUMAN (3-572): 6.73e-160: 472: 34.90		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	Hs
		897262 KLH10_HUMAN (26-573): 1.28e-155: 460: 31.03		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	Hs
		299532 KLH18_HUMAN (1-574): 9.48e-176: 510: 100.00		CSN4_HUMAN (1-397): 3.04e-62: 208: 15.87
+	Hs
		1153792 KLH10_HUMAN (26-573): 1.28e-155: 460: 31.03		CSN4_HUMAN (1-397): 3.04e-62: 208: 15.87
+	Hs
		1120829 KLH12_HUMAN (414-572): 3.15e-33: 135: 27.61		CSN3_HUMAN (1-423): 2.33e-144: 419: 100.00
+	Hs
		1350484 KLH13_HUMAN (431-573): 1.06e-27: 119: 25.33		CSN3_HUMAN (1-423): 2.33e-144: 419: 100.00
+	Dm
		1249187 Q9VK21_DROME (418-572): 7.12e-30: 126: 29.27		CSN3_DROME (1-423): 2.7e-116: 348: 50.79
+	Hs
		897257 KLH12_HUMAN (414-572): 3.15e-33: 135: 27.61		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	Hs
		897322 KLH13_HUMAN (431-573): 1.06e-27: 119: 25.33		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	Hs
		1120807 KLH12_HUMAN (414-572): 3.15e-33: 135: 27.61		CSN4_HUMAN (1-397): 3.04e-62: 208: 15.87
+	Hs
		897264 KLH24_HUMAN (282-384): 2.26e-10: 65.2: 26.92		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	Hs
		1311911 KLH13_HUMAN (431-573): 1.06e-27: 119: 25.33		CSN4_HUMAN (1-397): 3.04e-62: 208: 15.87