HitPredict

Interactor 1: TRIO (O75962)
Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)
Gene: TRIO

Interactor 2: RHOG (P84095)
Rho-related GTP-binding protein RhoG
Gene: RHOG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	31871319, 32203420, 25065758, unassigned2213
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~Ras, Ras~RhoGEF, Ras~SOS1_NGEF_PH
Common GO terms	GO:0005829 - cytosol GO:0042995 - cell projection GO:0098794 - postsynapse GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3097 Hs			1 191
+	Hs
		299534 TRIO_HUMAN (41-3097): 0: 2373: 100.00		RAC1_HUMAN (1-191): 1e-80: 239: 71.88
+	Hs
		299529 TRIO_HUMAN (41-3097): 0: 2373: 100.00		CDC42_HUMAN (1-191): 2.01e-77: 231: 60.73
+	Hs
		299530 TRIO_HUMAN (41-3097): 0: 2373: 100.00		RHOA_HUMAN (5-191): 2.01e-77: 231: 55.62
+	Hs
		238812 KALRN_HUMAN (53-3092): 0: 1937: 59.58		RAC1_HUMAN (1-191): 1e-80: 239: 71.88
+	Hs
		988495 ARHGP_HUMAN (1241-1632): 3.35e-119: 393: 34.00		RAC1_HUMAN (1-191): 1e-80: 239: 71.88
+	Hs
		955340 ARHGP_HUMAN (1241-1632): 3.35e-119: 393: 34.00		CDC42_HUMAN (1-191): 2.01e-77: 231: 60.73
+	Hs
		962227 ARHGP_HUMAN (1241-1632): 3.35e-119: 393: 34.00		RHOA_HUMAN (5-191): 2.01e-77: 231: 55.62
+	Hs
		319060 K0754_HUMAN (142-1887): 9.58e-103: 373: 11.01		RAC1_HUMAN (1-191): 1e-80: 239: 71.88
+	Hs
		319064 K0754_HUMAN (142-1887): 9.58e-103: 373: 11.01		RHOG_HUMAN (1-191): 1.42e-80: 239: 100.00
+	Hs
		319057 K0754_HUMAN (142-1887): 9.58e-103: 373: 11.01		RHOA_HUMAN (5-191): 2.01e-77: 231: 55.62
+	Hs
		319049 K0754_HUMAN (142-1887): 9.58e-103: 373: 11.01		RAC2_HUMAN (1-191): 3.6e-77: 230: 71.35
+	Hs
		319046 K0754_HUMAN (142-1887): 9.58e-103: 373: 11.01		RHOC_HUMAN (5-191): 1.31e-75: 226: 56.15
+	Hs
		319056 K0754_HUMAN (142-1887): 9.58e-103: 373: 11.01		RAC3_HUMAN (1-177): 2.18e-74: 223: 72.88
+	Ce
		1041914 Q7KPP4_CAEEL (789-2378): 6.19e-96: 348: 13.34		RAC1_CAEEL (1-191): 2.53e-81: 241: 66.49
+	Ce
		110134 Q7KPP4_CAEEL (789-2378): 6.19e-96: 348: 13.34		G5EBV3_CAEEL (2-191): 5.31e-78: 233: 60.00
+	Hs
		533818 MCF2_HUMAN (130-839): 2.01e-84: 301: 15.94		RAC1_HUMAN (1-191): 1e-80: 239: 71.88
+	Hs
		533815 MCF2_HUMAN (130-839): 2.01e-84: 301: 15.94		CDC42_HUMAN (1-191): 2.01e-77: 231: 60.73
+	Hs
		533816 MCF2_HUMAN (130-839): 2.01e-84: 301: 15.94		RHOA_HUMAN (5-191): 2.01e-77: 231: 55.62
+	Hs
		988618 SPT13_HUMAN (1225-1622): 5.69e-84: 293: 22.17		RAC1_HUMAN (1-191): 1e-80: 239: 71.88
+	Hs
		955486 SPT13_HUMAN (1225-1622): 5.69e-84: 293: 22.17		CDC42_HUMAN (1-191): 2.01e-77: 231: 60.73