HitPredict

Interactor 1: CDKL5 (O76039)
Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9)
Gene: CDKL5

Interactor 2: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0004672 - protein kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016301 - kinase activity and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 960 Hs			1 1130
+	Hs
		362123 CDK1_HUMAN (10-302): 8.29e-136: 410: 37.84		ABL1_HUMAN (1-1130): 0: 987: 100.00
+	Hs
		302103 CDKL5_HUMAN (1-960): 0: 762: 100.00		FYN_HUMAN (18-510): 0: 543: 38.64
+	Hs
		463219 SIK2_HUMAN (13-884): 4.2e-139: 440: 17.16		YES_HUMAN (5-510): 5.81e-179: 536: 39.42
+	Hs
		463339 CDK2_HUMAN (10-303): 1.35e-150: 449: 37.16		LYN_HUMAN (9-508): 2.82e-172: 518: 36.15
+	Dm
		362463 CDK1_DROME (10-300): 2.6e-133: 404: 36.40		ABL_DROME (38-886): 3e-175: 559: 45.92
+	Hs
		440029 CDK3_HUMAN (10-312): 1.27e-143: 431: 36.72		LCK_HUMAN (9-508): 2.02e-177: 531: 38.49
+	Hs
		443146 CDK1_HUMAN (10-302): 8.29e-136: 410: 37.84		SRC_HUMAN (13-510): 0: 547: 38.58
+	Hs
		440292 CDK1_HUMAN (10-302): 8.29e-136: 410: 37.84		FYN_HUMAN (18-510): 0: 543: 38.64
+	Mm
		813505 CDK5_MOUSE (10-303): 3.78e-134: 406: 39.19		FYN_MOUSE (18-510): 0: 542: 38.64
+	Hs
		443125 CDK1_HUMAN (10-302): 8.29e-136: 410: 37.84		YES_HUMAN (5-510): 5.81e-179: 536: 39.42
+	Hs
		443133 CDK1_HUMAN (10-302): 8.29e-136: 410: 37.84		FGR_HUMAN (2-510): 8.58e-178: 533: 38.80
+	Hs
		439899 CDK1_HUMAN (10-302): 8.29e-136: 410: 37.84		LCK_HUMAN (9-508): 2.02e-177: 531: 38.49
+	Hs
		443126 CDK1_HUMAN (10-302): 8.29e-136: 410: 37.84		LYN_HUMAN (9-508): 2.82e-172: 518: 36.15
+	Hs
		834240 MAST1_HUMAN (11-958): 2.36e-134: 442: 16.90		CSK_HUMAN (61-500): 3.6e-155: 471: 37.72
+	Hs
		443271 CDK1_HUMAN (10-302): 8.29e-136: 410: 37.84		BLK_HUMAN (9-508): 9.47e-165: 498: 38.33
+	Hs
		443245 CDK1_HUMAN (10-302): 8.29e-136: 410: 37.84		CSK_HUMAN (61-500): 3.6e-155: 471: 37.72
+	Hs
		463155 CDK20_HUMAN (10-302): 3.43e-56: 199: 40.00		YES_HUMAN (5-510): 5.81e-179: 536: 39.42