HitPredict

Interactor 1: CDKL5 (O76039)
Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9)
Gene: CDKL5

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005813 - centrosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 960 Hs			1 217
+	Hs
		302101 CDKL5_HUMAN (1-960): 0: 762: 100.00		ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46
+	Hs
		302103 CDKL5_HUMAN (1-960): 0: 762: 100.00		FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58
+	Hs
		440029 CDK3_HUMAN (10-312): 1.27e-143: 431: 36.72		LCK_HUMAN (3-202): 7.98e-34: 128: 28.44
+	Hs
		834240 MAST1_HUMAN (11-958): 2.36e-134: 442: 16.90		CSK_HUMAN (2-139): 3.94e-24: 100: 36.24
+	Hs
		439899 CDK1_HUMAN (10-302): 8.29e-136: 410: 37.84		LCK_HUMAN (3-202): 7.98e-34: 128: 28.44
+	Hs
		443245 CDK1_HUMAN (10-302): 8.29e-136: 410: 37.84		CSK_HUMAN (2-139): 3.94e-24: 100: 36.24
+	Hs
		463339 CDK2_HUMAN (10-303): 1.35e-150: 449: 37.16		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47
+	Hs
		463219 SIK2_HUMAN (13-884): 4.2e-139: 440: 17.16		YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33
+	Hs
		362123 CDK1_HUMAN (10-302): 8.29e-136: 410: 37.84		ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46
+	Dm
		362463 CDK1_DROME (10-300): 2.6e-133: 404: 36.40		ABL_DROME (4-135): 1.01e-22: 97.4: 37.68
+	Hs
		440292 CDK1_HUMAN (10-302): 8.29e-136: 410: 37.84		FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58
+	Hs
		443133 CDK1_HUMAN (10-302): 8.29e-136: 410: 37.84		FGR_HUMAN (98-215): 3.91e-12: 66.6: 20.00
+	Hs
		443125 CDK1_HUMAN (10-302): 8.29e-136: 410: 37.84		YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33
+	Mm
		813505 CDK5_MOUSE (10-303): 3.78e-134: 406: 39.19		FYN_MOUSE (161-215): 9.17e-13: 68.5: 31.58
+	Hs
		443146 CDK1_HUMAN (10-302): 8.29e-136: 410: 37.84		SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58
+	Hs
		443126 CDK1_HUMAN (10-302): 8.29e-136: 410: 37.84		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47
+	Hs
		463155 CDK20_HUMAN (10-302): 3.43e-56: 199: 40.00		YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33