HitPredict

Interactor 1: CCNB2 (O95067)
G2/mitotic-specific cyclin-B2
Gene: CCNB2

Interactor 2: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.975

Property	Details
Experiments	26496610, 33961781, 8313904, 25852190, 26186194, 28514442, 32707033, 36736316, 23602568
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol and 2 others more... GO:0016020 - membrane GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 398 Hs			1 297
+	Hs
		303829 CCNB2_HUMAN (1-398): 1.14e-149: 431: 100.00		CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32
+	Hs
		303843 CCNB2_HUMAN (1-398): 1.14e-149: 431: 100.00		CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12
+	Hs
		538471 CCNB1_HUMAN (1-394): 1.7e-133: 391: 44.88		CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32
+	Hs
		303844 CCNB2_HUMAN (1-398): 1.14e-149: 431: 100.00		CDK17_HUMAN (1-297): 6.74e-126: 370: 54.36
+	Gg
		533892 CCNB2_CHICK (1-395): 4.38e-138: 401: 69.25		CDK1_CHICK (1-296): 5.72e-141: 400: 92.23
+	Hs
		538521 CCNB1_HUMAN (1-394): 1.7e-133: 391: 44.88		CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78
+	Hs
		414711 CCNB1_HUMAN (1-394): 1.7e-133: 391: 44.88		CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00
+	Mm
		509465 CCNB1_MOUSE (1-395): 1e-130: 384: 44.39		CDK1_MOUSE (1-297): 4.35e-142: 403: 96.97
+	Xl
		526765 CCNB1_XENLA (1-395): 2.95e-129: 379: 47.37		CDK1A_XENLA (1-296): 1.57e-141: 402: 87.50
+	Hs
		538522 CCNB1_HUMAN (1-394): 1.7e-133: 391: 44.88		CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12
+	Hs
		625350 CCNA1_HUMAN (2-388): 2.46e-115: 345: 29.46		CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32
+	Hs
		414855 CCNA1_HUMAN (2-388): 2.46e-115: 345: 29.46		CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00
+	Mm
		956329 CCNA1_MOUSE (16-388): 4.58e-114: 341: 30.85		CDK2_MOUSE (1-297): 2.06e-140: 401: 55.94
+	At
		621661 CCB12_ARATH (3-394): 4.45e-110: 332: 28.76		CDKA1_ARATH (1-290): 1.2e-137: 392: 67.01
+	At
		621690 CCA11_ARATH (1-389): 3.97e-108: 327: 25.25		CDKA1_ARATH (1-290): 1.2e-137: 392: 67.01
+	At
		639373 CCB24_ARATH (19-387): 2.16e-111: 334: 30.65		CKB11_ARATH (1-292): 6.81e-132: 378: 52.12
+	At
		639340 CCB12_ARATH (3-394): 4.45e-110: 332: 28.76		CKB11_ARATH (1-292): 6.81e-132: 378: 52.12
+	At
		1106906 CCB12_ARATH (3-394): 4.45e-110: 332: 28.76		CKB21_ARATH (1-295): 9.26e-131: 375: 53.14
+	At
		1106907 CCB12_ARATH (3-394): 4.45e-110: 332: 28.76		CKB22_ARATH (1-295): 4.69e-130: 373: 57.10
+	At
		1103350 CCB12_ARATH (3-394): 4.45e-110: 332: 28.76		CKB12_ARATH (1-292): 5.76e-128: 368: 53.72