Protein: HIC1
Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29)

Gene: HIC1
Organism: Homo sapiens
Interactions: 36
UniProt ID: Q14526

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003700 - DNA-binding transcription factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1127695

HIC1
Hypermethylated in cancer 1 protein

2

18

Small-scale

0.743

High

1040804

MECOM
Histone-lysine N-methyltransferase MECOM

1

19

Small-scale

0.724

High

1127701

SIR1
NAD-dependent protein deacetylase sirtuin-1

4

4

Small-scale

0.683

High

941437

CTBP2
C-terminal-binding protein 2

3

5

Small-scale

0.680

High

1127702

HIC2
Hypermethylated in cancer 2 protein

1

20

Small-scale

0.656

High

1127703

CRBN
Protein cereblon

1

1

Small-scale

0.647

High

1102536

MTA1
Metastasis-associated protein MTA1

3

1

Small-scale

0.640

High

827781

STAT3
Signal transducer and activator of transcription 3

2

2

Small-scale

0.624

High

1103165

CTBP1
C-terminal-binding protein 1

2

5

Small-scale

0.620

High

1114816

CUL4A
Cullin-4A

1

20

High-throughput

0.618

High

1127704

BC11B
B-cell lymphoma/leukemia 11B

1

20

Small-scale

0.618

High

993568

UBC9
SUMO-conjugating enzyme UBC9

2

1

Small-scale

0.595

High

1127706

TF7L2
Transcription factor 7-like 2

1

11

Small-scale

0.589

High

1127698

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.575

High

154691

ARI1A
AT-rich interactive domain-containing protein 1A

1

2

Small-scale

0.573

High

210277

PHF1
PHD finger protein 1

1

2

Small-scale

0.552

High

1127699

PHF19
PHD finger protein 19

1

2

Small-scale

0.552

High

297604

PIAS1
E3 SUMO-protein ligase PIAS1

1

1

Small-scale

0.501

High

297809

PIAS2
E3 SUMO-protein ligase PIAS2

1

1

Small-scale

0.501

High

1127705

SENP3
Sentrin-specific protease 3

1

1

Small-scale

0.501

High

285276

EED
Polycomb protein EED

1

2

Small-scale

0.479

High

684997

DNMT1
DNA

1

4

Small-scale

0.479

High

764750

CTNB1
Catenin beta-1

1

8

Small-scale

0.479

High

940962

HDAC4
Histone deacetylase 4

1

4

Small-scale

0.479

High

1066305

RBBP4
Histone-binding protein RBBP4

1

1

Small-scale

0.479

High

1088340

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

4

Small-scale

0.479

High

1127696

SUZ12
Polycomb protein SUZ12

1

1

Small-scale

0.479

High

1127697

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

Small-scale

0.479

High

1127708

DNM3B
DNA

1

2

Small-scale

0.479

High

1127709

DNM3A
DNA

1

2

Small-scale

0.479

High

352141

MBD3
Methyl-CpG-binding domain protein 3

1

0

Small-scale

0.458

High

601669

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.458

High

1127700

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

1127707

GRHL1
Grainyhead-like protein 1 homolog

1

1

High-throughput

0.445

High

640513

TA2R
Thromboxane A2 receptor

1

2

Small-scale

0.437

High


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Last updated: 11Aug2025