HitPredict

Interactor 1: ZBT7A (O95365)
Zinc finger and BTB domain-containing protein 7A (Factor binding IST protein 1) (FBI-1) (Factor that binds to inducer of short transcripts protein 1) (HIV-1 1st-binding protein 1) (Leukemia/lymphoma-related factor) (POZ and Krueppel erythroid myeloid ontogenic factor) (POK erythroid myeloid ontogenic factor) (Pokemon) (Pokemon 1) (TTF-I-interacting peptide 21) (TIP21) (Zinc finger protein 857A)
Gene: ZBTB7A

Interactor 2: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26446488
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003677 - DNA binding GO:0005634 - nucleus GO:0035861 - site of double-strand break GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 584 Hs			1 1014
+	Hs
		455793 ZBT18_HUMAN (11-495): 2.19e-94: 300: 23.72		PARP1_HUMAN (1-1014): 0: 1362: 100.00
+	Hs
		196554 ZBT24_HUMAN (222-571): 2.69e-64: 225: 17.96		PARP1_HUMAN (1-1014): 0: 1362: 100.00
+	Hs
		455352 ZBT16_HUMAN (157-514): 2e-48: 181: 21.60		PARP1_HUMAN (1-1014): 0: 1362: 100.00
+	Hs
		455237 ZNF83_HUMAN (368-484): 1.17e-18: 91.3: 36.75		PARP1_HUMAN (1-1014): 0: 1362: 100.00
+	Hs
		455467 OZF_HUMAN (402-486): 3.29e-14: 75.5: 35.29		PARP1_HUMAN (1-1014): 0: 1362: 100.00
+	Mm
		291879 ZBT7B_MOUSE (1-500): 4.56e-109: 339: 36.92		PARP2_MOUSE (494-1014): 0: 611: 39.66
+	Mm
		1145216 ZBT7B_MOUSE (1-500): 4.56e-109: 339: 36.92		PAR12_MOUSE (688-1006): 5.29e-46: 179: 15.88
+	Mm
		1145201 ZBT7B_MOUSE (1-500): 4.56e-109: 339: 36.92		Q80ZH7_MOUSE (4-94): 1.01e-26: 119: 26.26
+	Hs
		1187733 ZBT18_HUMAN (11-495): 2.19e-94: 300: 23.72		ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71
+	Hs
		1187770 GZF1_HUMAN (155-497): 1.77e-61: 217: 17.39		ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71
+	Hs
		485252 TZAP_HUMAN (345-502): 4.16e-44: 168: 26.84		ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71
+	Hs
		485364 GLI4_HUMAN (434-553): 3.85e-20: 94.4: 25.00		ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71