HitPredict

Interactor 1: DIRA3 (O95661)
GTP-binding protein Di-Ras3 (Distinct subgroup of the Ras family member 3) (Rho-related GTP-binding protein RhoI)
Gene: DIRAS3

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26186194
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 229 Hs			1 193
+	Hs
		900355 RAB1A_HUMAN (26-227): 7.65e-82: 244: 22.97		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		918847 RAB1A_HUMAN (26-227): 7.65e-82: 244: 22.97		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		436244 RAB1A_HUMAN (26-227): 7.65e-82: 244: 22.97		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		900882 RAB1B_HUMAN (32-227): 2.55e-79: 238: 23.76		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		918849 RAB1A_HUMAN (26-227): 7.65e-82: 244: 22.97		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		925600 RAB1B_HUMAN (32-227): 2.55e-79: 238: 23.76		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		893872 RAB1A_HUMAN (26-227): 7.65e-82: 244: 22.97		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545307 RAB1A_HUMAN (26-227): 7.65e-82: 244: 22.97		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		436498 RAB1B_HUMAN (32-227): 2.55e-79: 238: 23.76		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		913995 RB11A_HUMAN (33-227): 1.96e-77: 233: 23.33		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		894409 RAB1B_HUMAN (32-227): 2.55e-79: 238: 23.76		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		892305 RAB1A_HUMAN (26-227): 7.65e-82: 244: 22.97		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		900511 RB11B_HUMAN (33-227): 1.78e-75: 228: 22.64		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		915582 RAB1A_HUMAN (26-227): 7.65e-82: 244: 22.97		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		893868 RB11A_HUMAN (33-227): 1.96e-77: 233: 23.33		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545305 RB11A_HUMAN (33-227): 1.96e-77: 233: 23.33		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		894052 RB11B_HUMAN (33-227): 1.78e-75: 228: 22.64		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		120378 RAB1A_HUMAN (26-227): 7.65e-82: 244: 22.97		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98
+	Hs
		913991 RB11A_HUMAN (33-227): 1.96e-77: 233: 23.33		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		120457 RB11B_HUMAN (33-227): 1.78e-75: 228: 22.64		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98