Protein: PKHG7
Pleckstrin homology domain-containing family G member 7 (PH domain-containing family G member 7)

Gene: PKHG7, PLEKHG7
Organism: Homo sapiens
Interactions: 173
UniProt ID: Q6ZR37

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0007266 - Rho protein signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

245995

KIF1B
Kinesin-like protein KIF1B

1

9

High-throughput

0.594

High

901330

RAB7A
Ras-related protein Rab-7a

1

2

High-throughput

0.594

High

174254

ARHGA
Rho guanine nucleotide exchange factor 10

1

15

High-throughput

0.575

High

1085505

ARHG5
Rho guanine nucleotide exchange factor 5

1

15

High-throughput

0.575

High

1187156

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

1

4

High-throughput

0.575

High

1201838

PKHG4
Puratrophin-1

1

15

High-throughput

0.575

High

1251247

DNMBP
Dynamin-binding protein

1

16

High-throughput

0.575

High

1253665

RHG35
Rho GTPase-activating protein 35

1

10

High-throughput

0.575

High

1253686

MAGD1
Melanoma-associated antigen D1

3

2

High-throughput

0.569

High

254167

CTND1
Catenin delta-1

2

12

High-throughput

0.521

High

522447

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

2

2

High-throughput

0.521

High

1149100

SF3A1
Splicing factor 3A subunit 1

2

4

High-throughput

0.521

High

1253648

MYCBP
c-Myc-binding protein

2

1

High-throughput

0.521

High

1253674

ANFY1
Rabankyrin-5

2

12

High-throughput

0.521

High

159714

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

High-throughput

0.514

High

1104838

SNTB2
Beta-2-syntrophin

1

20

High-throughput

0.514

High

1253638

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

10

High-throughput

0.514

High

847413

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

2

4

High-throughput

0.504

High

1231749

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

2

1

High-throughput

0.504

High

1253652

AASD1
Alanyl-tRNA editing protein Aarsd1

2

1

High-throughput

0.504

High

1109833

HDAC1
Histone deacetylase 1

1

10

High-throughput

0.470

High

1253651

COR1B
Coronin-1B

1

8

High-throughput

0.470

High

109432

G5E9A7
DM1 locus, WD repeat containing

1

11

High-throughput

0.470

High

225617

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

1

High-throughput

0.470

High

242064

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.470

High

301506

WFS1
Wolframin

1

1

High-throughput

0.470

High

415664

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.470

High

442375

GELS
Gelsolin

1

3

High-throughput

0.470

High

650249

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.470

High

705427

GRN
Progranulin

1

1

High-throughput

0.470

High

767245

MERL
Merlin

1

9

High-throughput

0.470

High

791478

SYUA
Alpha-synuclein

1

2

High-throughput

0.470

High

843693

HD
Huntingtin

1

2

High-throughput

0.470

High

876032

TCPE
T-complex protein 1 subunit epsilon

1

1

High-throughput

0.470

High

927370

ATX1
Ataxin-1

1

1

High-throughput

0.470

High

1133890

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

12

High-throughput

0.470

High

1253622

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

6

High-throughput

0.470

High

1253624

Q86WV8
TSC complex subunit 1

1

2

High-throughput

0.470

High

1253642

APBB2
Amyloid beta precursor protein binding family B member 2

1

2

High-throughput

0.470

High

1253680

UBQL1
Ubiquilin-1

1

7

High-throughput

0.470

High

1253684

RNF11
RING finger protein 11

1

2

High-throughput

0.470

High

1253687

Q9Y649
GW128

1

1

High-throughput

0.470

High

1116665

RIN1
Ras and Rab interactor 1

1

7

High-throughput

0.445

High

471098

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.437

High

472835

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

7

High-throughput

0.437

High

866734

CAZA2
F-actin-capping protein subunit alpha-2

1

3

High-throughput

0.437

High

987080

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

7

High-throughput

0.437

High

1119956

CIRBP
Cold-inducible RNA-binding protein

1

2

High-throughput

0.437

High

1131740

LBR
Delta(14)-sterol reductase LBR

1

3

High-throughput

0.437

High

1141714

EEA1
Early endosome antigen 1

1

6

High-throughput

0.437

High

1148603

SF3A2
Splicing factor 3A subunit 2

1

2

High-throughput

0.437

High

1253685

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

7

High-throughput

0.437

High

161729

APAF
Apoptotic protease-activating factor 1

1

11

High-throughput

0.407

High

177895

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

11

High-throughput

0.407

High

188313

HDAC3
Histone deacetylase 3

1

6

High-throughput

0.407

High

193788

PER1
Period circadian protein homolog 1

1

2

High-throughput

0.407

High

231719

PEX1
Peroxisomal ATPase PEX1

1

3

High-throughput

0.407

High

290329

KS6A4
Ribosomal protein S6 kinase alpha-4

1

9

High-throughput

0.407

High

295749

AP1G2
AP-1 complex subunit gamma-like 2

1

8

High-throughput

0.407

High

298606

RAD17
Cell cycle checkpoint protein RAD17

1

2

High-throughput

0.407

High

315711

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.407

High

343607

OXSR1
Serine/threonine-protein kinase OSR1

1

10

High-throughput

0.407

High

457512

TBB5
Tubulin beta chain

1

8

High-throughput

0.407

High

537380

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.407

High

636103

CD11B
Cyclin-dependent kinase 11B

1

1

High-throughput

0.407

High

702986

DPOD1
DNA polymerase delta catalytic subunit

1

1

High-throughput

0.407

High

777301

AHR
Aryl hydrocarbon receptor

1

2

High-throughput

0.407

High

829232

RFC3
Replication factor C subunit 3

1

1

High-throughput

0.407

High

832540

ETV3
ETS translocation variant 3

1

1

High-throughput

0.407

High

839469

PI4KA
Phosphatidylinositol 4-kinase alpha

1

5

High-throughput

0.407

High

888791

VPS41
Vacuolar protein sorting-associated protein 41 homolog

1

3

High-throughput

0.407

High

896402

ERF
ETS domain-containing transcription factor ERF

1

2

High-throughput

0.407

High

897316

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.407

High

898098

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

9

High-throughput

0.407

High

996997

TBA4A
Tubulin alpha-4A chain

1

9

High-throughput

0.407

High

1007575

PRAME
Melanoma antigen preferentially expressed in tumors

1

2

High-throughput

0.407

High

1029701

FOXK2
Forkhead box protein K2

1

1

High-throughput

0.407

High

1060456

DPOE1
DNA polymerase epsilon catalytic subunit A

1

1

High-throughput

0.407

High

1093373

TRI32
E3 ubiquitin-protein ligase TRIM32

1

7

High-throughput

0.407

High

1110362

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

10

High-throughput

0.407

High

1110478

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

8

High-throughput

0.407

High

1112246

PEX6
Peroxisomal ATPase PEX6

1

3

High-throughput

0.407

High

1124476

MAP7
Ensconsin

1

20

High-throughput

0.407

High

1134959

CUL7
Cullin-7

1

1

High-throughput

0.407

High

1191852

TBB8
Tubulin beta-8 chain

1

8

High-throughput

0.407

High

1200919

WDR81
WD repeat-containing protein 81

1

11

High-throughput

0.407

High

1212171

ODAD2
Outer dynein arm-docking complex subunit 2

1

11

High-throughput

0.407

High

1220581

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.407

High

1245035

TRI65
E3 ubiquitin-protein ligase TRIM65

1

5

High-throughput

0.407

High

1245305

WDR59
GATOR2 complex protein WDR59

1

14

High-throughput

0.407

High

1246848

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.407

High

1253620

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

4

High-throughput

0.407

High

1253621

TBA1A
Tubulin alpha-1A chain

1

10

High-throughput

0.407

High

1253623

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

9

High-throughput

0.407

High

1253626

MEX3D
RNA-binding protein MEX3D

1

3

High-throughput

0.407

High

1253628

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

12

High-throughput

0.407

High

1253633

NAV1
Neuron navigator 1

1

9

High-throughput

0.407

High

1253634

WDR36
WD repeat-containing protein 36

1

11

High-throughput

0.407

High

1253635

SHKB1
SH3KBP1-binding protein 1

1

18

High-throughput

0.407

High

1253636

NEK9
Serine/threonine-protein kinase Nek9

1

10

High-throughput

0.407

High

1253637

CTF18
Chromosome transmission fidelity protein 18 homolog

1

2

High-throughput

0.407

High

1253639

LAR4B
La-related protein 4B

1

4

High-throughput

0.407

High

1253644

VP33A
Vacuolar protein sorting-associated protein 33A

1

6

High-throughput

0.407

High

1253645

SPTCS
Spatacsin

1

1

High-throughput

0.407

High

1253647

IF140
Intraflagellar transport protein 140 homolog

1

7

High-throughput

0.407

High

1253649

METH
Methionine synthase

1

1

High-throughput

0.407

High

1253650

TBA1C
Tubulin alpha-1C chain

1

10

High-throughput

0.407

High

1253654

AFG2B
ATPase family gene 2 protein homolog B

1

3

High-throughput

0.407

High

1253656

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

4

High-throughput

0.407

High

1253658

CLPB
Mitochondrial disaggregase

1

2

High-throughput

0.407

High

1253660

ESRP2
Epithelial splicing regulatory protein 2

1

2

High-throughput

0.407

High

1253662

IF122
Intraflagellar transport protein 122 homolog

1

10

High-throughput

0.407

High

1253663

TF7L2
Transcription factor 7-like 2

1

1

High-throughput

0.407

High

1253664

AAAS
Aladin

1

7

High-throughput

0.407

High

1253668

NALP2
NACHT, LRR and PYD domains-containing protein 2

1

1

High-throughput

0.407

High

1253670

RTEL1
Regulator of telomere elongation helicase 1

1

2

High-throughput

0.407

High

1253671

POGK
Pogo transposable element with KRAB domain

1

3

High-throughput

0.407

High

1253672

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

2

High-throughput

0.407

High

1253675

NCDN
Neurochondrin

1

1

High-throughput

0.407

High

1253676

CPNE7
Copine-7

1

4

High-throughput

0.407

High

1253677

HOOK1
Protein Hook homolog 1

1

11

High-throughput

0.407

High

1253678

MTUS1
Microtubule-associated tumor suppressor 1

1

14

High-throughput

0.407

High

1253681

SNX6
Sorting nexin-6

1

2

High-throughput

0.407

High

1253683

TRI33
E3 ubiquitin-protein ligase TRIM33

1

8

High-throughput

0.407

High

295195

EIF3G
Eukaryotic translation initiation factor 3 subunit G

2

0

High-throughput

0.298

High

724765

METK2
S-adenosylmethionine synthase isoform type-2

2

0

High-throughput

0.298

High

1118895

BYST
Bystin

2

0

High-throughput

0.298

High

1253625

RLGPB
Ral GTPase-activating protein subunit beta

2

0

High-throughput

0.288

High

47355

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

184859

SPTC1
Serine palmitoyltransferase 1

1

0

High-throughput

0.268

Low

638853

AGT1
Alanine--glyoxylate aminotransferase

1

0

High-throughput

0.268

Low

898488

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.268

Low

928888

LIPR2
Pancreatic lipase-related protein 2

1

0

High-throughput

0.249

Low

1253630

TOM5
Mitochondrial import receptor subunit TOM5 homolog

1

0

High-throughput

0.249

Low

1253673

CPSF2
Cleavage and polyadenylation specificity factor subunit 2

1

0

High-throughput

0.249

Low

65502

MROH6
Maestro heat-like repeat-containing protein family member 6

1

0

High-throughput

0.232

Low

67477

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

High-throughput

0.232

Low

124383

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.232

Low

213178

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.232

Low

216726

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.232

Low

841052

HELZ
Probable helicase with zinc finger domain

1

0

High-throughput

0.232

Low

873404

LSS
Lanosterol synthase

1

0

High-throughput

0.232

Low

905601

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.232

Low

908757

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.232

Low

1017785

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.232

Low

1065816

SLFN5
Schlafen family member 5

1

0

High-throughput

0.232

Low

1112367

MTMR1
Phosphatidylinositol-3-phosphate phosphatase MTMR1

1

0

High-throughput

0.232

Low

1152916

NAB2
NGFI-A-binding protein 2

1

0

High-throughput

0.232

Low

1180646

AP5B1
AP-5 complex subunit beta-1

1

0

High-throughput

0.232

Low

1185194

EDRF1
Erythroid differentiation-related factor 1

1

0

High-throughput

0.232

Low

1206983

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

0

High-throughput

0.232

Low

1225934

F91A1
Protein FAM91A1

1

0

High-throughput

0.232

Low

1228534

HAUS3
HAUS augmin-like complex subunit 3

1

0

High-throughput

0.232

Low

1238215

GPAT2
Glycerol-3-phosphate acyltransferase 2, mitochondrial

1

0

High-throughput

0.232

Low

1244255

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

1

0

High-throughput

0.232

Low

1253627

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.232

Low

1253629

FCSK
L-fucose kinase

1

0

High-throughput

0.232

Low

1253631

BANP
Protein BANP

1

0

High-throughput

0.232

Low

1253632

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.232

Low

1253640

SYMPK
Symplekin

1

0

High-throughput

0.232

Low

1253641

N42L2
NEDD4-binding protein 2-like 2

1

0

High-throughput

0.232

Low

1253643

PLPL2
Patatin-like phospholipase domain-containing protein 2

1

0

High-throughput

0.232

Low

1253646

GCP6
Gamma-tubulin complex component 6

1

0

High-throughput

0.232

Low

1253653

TBCD
Tubulin-specific chaperone D

1

0

High-throughput

0.232

Low

1253655

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.232

Low

1253657

TNG6
Transport and Golgi organization protein 6 homolog

1

0

High-throughput

0.232

Low

1253659

ADNP
Activity-dependent neuroprotector homeobox protein

1

0

High-throughput

0.232

Low

1253661

BCAS3
BCAS3 microtubule associated cell migration factor

1

0

High-throughput

0.232

Low

1253666

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.232

Low

1253667

RNF12
E3 ubiquitin-protein ligase RLIM

1

0

High-throughput

0.232

Low

1253669

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.232

Low

1253679

PALD
Paladin

1

0

High-throughput

0.232

Low

1253682

TTF2
Transcription termination factor 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025