HitPredict

Interactor 1: EYA4 (O95677)
Eyes absent homolog 4 (EC 3.1.3.48)
Gene: EYA4

Interactor 2: SIX1 (Q15475)
Homeobox protein SIX1 (Sine oculis homeobox homolog 1)
Gene: SIX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	26186194, 28514442, 33961781, 28675297, 38360978
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Hydrolase~SIX1_SD
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0048839 - inner ear development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 639 Hs			1 284
+	Hs
		318733 EYA4_HUMAN (1-639): 0: 650: 100.00		SIX2_HUMAN (1-284): 1.38e-82: 251: 72.97
+	Hs
		92587 E9PLN6_HUMAN (1-639): 0: 618: 94.52		SIX1_HUMAN (1-284): 4.94e-93: 278: 100.00
+	Hs
		318748 EYA4_HUMAN (1-639): 0: 650: 100.00		SIX4_HUMAN (5-283): 1.69e-72: 239: 48.17
+	Mm
		1143690 EYA4_MOUSE (1-639): 0: 606: 91.24		SIX1_MOUSE (1-284): 2.98e-92: 276: 99.30
+	Hs
		92588 E9PLN6_HUMAN (1-639): 0: 618: 94.52		SIX2_HUMAN (1-284): 1.38e-82: 251: 72.97
+	Hs
		318670 EYA4_HUMAN (1-639): 0: 650: 100.00		SIX5_HUMAN (2-248): 1.85e-54: 189: 46.54
+	Hs
		118562 EYA2_HUMAN (120-639): 0: 536: 57.12		SIX1_HUMAN (1-284): 4.94e-93: 278: 100.00
+	Mm
		956885 EYA1_MOUSE (82-639): 1.16e-177: 519: 71.83		SIX1_MOUSE (1-284): 2.98e-92: 276: 99.30
+	Hs
		1074456 EYA1_HUMAN (84-639): 1.83e-176: 516: 72.13		SIX1_HUMAN (1-284): 4.94e-93: 278: 100.00
+	Hs
		118611 EYA2_HUMAN (120-639): 0: 536: 57.12		SIX2_HUMAN (1-284): 1.38e-82: 251: 72.97
+	Hs
		118619 EYA2_HUMAN (120-639): 0: 536: 57.12		SIX4_HUMAN (5-283): 1.69e-72: 239: 48.17
+	Mm
		956886 EYA1_MOUSE (82-639): 1.16e-177: 519: 71.83		SIX2_MOUSE (1-284): 1.1e-83: 254: 73.06
+	Hs
		1304296 EYA1_HUMAN (84-639): 1.83e-176: 516: 72.13		SIX2_HUMAN (1-284): 1.38e-82: 251: 72.97
+	Mm
		139225 EYA2_MOUSE (104-639): 6.38e-180: 522: 56.72		SIX4_MOUSE (5-283): 9.09e-75: 244: 48.51
+	Mm
		956884 EYA1_MOUSE (82-639): 1.16e-177: 519: 71.83		SIX4_MOUSE (5-283): 9.09e-75: 244: 48.51
+	Hs
		1304297 EYA1_HUMAN (84-639): 1.83e-176: 516: 72.13		SIX4_HUMAN (5-283): 1.69e-72: 239: 48.17
+	Mm
		956887 EYA1_MOUSE (82-639): 1.16e-177: 519: 71.83		SIX3_MOUSE (1-250): 7.3e-64: 205: 51.18
+	Mm
		936193 EYA1_MOUSE (82-639): 1.16e-177: 519: 71.83		SIX5_MOUSE (1-283): 3.72e-56: 194: 41.39
+	Hs
		1230644 EYA1_HUMAN (84-639): 1.83e-176: 516: 72.13		SIX5_HUMAN (2-248): 1.85e-54: 189: 46.54
+	Hs
		1230645 EYA3_HUMAN (89-639): 7.83e-168: 493: 53.12		SIX5_HUMAN (2-248): 1.85e-54: 189: 46.54