HitPredict

Interactor 1: AP2A1 (O95782)
AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)
Gene: AP2A1

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019901 - protein kinase binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 977 Hs			1 758
+	Mm
		497920 AP2A1_MOUSE (1-977): 0: 893: 97.75		TAU_MOUSE (1-758): 1.4e-69: 244: 70.17
+	Hs
		302095 AP2A2_HUMAN (1-977): 0: 832: 76.97		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Rn
		94239 Q66HM2_RAT (1-977): 0: 845: 79.39		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Rn
		577190 AP2A2_RAT (1-977): 0: 841: 79.18		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Hs
		496790 AP2B1_HUMAN (34-972): 0: 676: 17.11		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		203194 AP2A1_HUMAN (1-977): 0: 904: 100.00		SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76
+	Hs
		496926 AP1B1_HUMAN (34-972): 0: 668: 18.15		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Rn
		581970 AP2B1_RAT (34-972): 0: 676: 17.11		TAU_RAT (1-758): 4.86e-75: 260: 71.47
+	Rn
		94193 AP2B1_RAT (34-972): 0: 676: 17.11		F1LST4_RAT (1-757): 8.59e-75: 260: 71.56
+	Rn
		1144064 Q66HM2_RAT (1-977): 0: 845: 79.39		SYNJ1_RAT (72-557): 4.95e-13: 75: 12.10
+	Mm
		498136 AP2B1_MOUSE (34-972): 0: 676: 17.01		TAU_MOUSE (1-758): 1.4e-69: 244: 70.17
+	Hs
		212589 AP1G1_HUMAN (1-864): 0: 612: 23.74		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		150164 AP3D1_HUMAN (11-746): 3.68e-150: 476: 20.55		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		926047 AP2B1_HUMAN (34-972): 0: 676: 17.11		MAGL2_HUMAN (1-739): 1.99e-19: 95.9: 10.23
+	Hs
		203219 AP2B1_HUMAN (34-972): 0: 676: 17.11		SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76
+	Hs
		203223 AP1B1_HUMAN (34-972): 0: 668: 18.15		SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76