HitPredict

Interactor 1: CCNB2 (O95067)
G2/mitotic-specific cyclin-B2
Gene: CCNB2

Interactor 2: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.949

Property	Details
Experiments	15232106, 26186194, 28514442, 33961781, 23455922, unassigned3799
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, protein array, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005813 - centrosome and 2 others more... GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 398 Hs			1 298
+	Hs
		573751 CCNB1_HUMAN (1-394): 1.71e-133: 391: 44.88		CDK2_HUMAN (1-298): 3.17e-166: 464: 100.00
+	Hs
		325458 CCNB2_HUMAN (1-398): 1.14e-149: 431: 100.00		CDK1_HUMAN (1-289): 2.35e-143: 407: 66.90
+	Hs
		573801 CCNB1_HUMAN (1-394): 1.71e-133: 391: 44.88		CDK3_HUMAN (1-294): 4.77e-154: 434: 76.87
+	Hs
		325481 CCNB2_HUMAN (1-398): 1.14e-149: 431: 100.00		CDK5_HUMAN (1-292): 4.84e-138: 393: 59.39
+	Hs
		667764 CCNA1_HUMAN (2-388): 2.47e-115: 345: 29.46		CDK2_HUMAN (1-298): 3.17e-166: 464: 100.00
+	Gg
		568872 CCNB2_CHICK (1-395): 4.4e-138: 401: 69.25		CDK1_CHICK (1-291): 2.57e-142: 404: 67.12
+	Hs
		443152 CCNB1_HUMAN (1-394): 1.71e-133: 391: 44.88		CDK1_HUMAN (1-289): 2.35e-143: 407: 66.90
+	Hs
		325482 CCNB2_HUMAN (1-398): 1.14e-149: 431: 100.00		CDK17_HUMAN (1-296): 1.3e-122: 362: 52.53
+	Mm
		543009 CCNB1_MOUSE (1-395): 1.01e-130: 384: 44.39		CDK1_MOUSE (1-289): 2.48e-142: 404: 66.21
+	Xl
		561231 CCNB1_XENLA (1-395): 2.96e-129: 379: 47.37		CDK1A_XENLA (1-291): 3.46e-143: 406: 67.12
+	Mm
		1021258 CCNA1_MOUSE (16-388): 4.6e-114: 341: 30.85		CDK2_MOUSE (1-298): 3.96e-157: 443: 85.26
+	Hs
		573802 CCNB1_HUMAN (1-394): 1.71e-133: 391: 44.88		CDK5_HUMAN (1-292): 4.84e-138: 393: 59.39
+	Hs
		443299 CCNA1_HUMAN (2-388): 2.47e-115: 345: 29.46		CDK1_HUMAN (1-289): 2.35e-143: 407: 66.90
+	Hs
		573777 CCNB1_HUMAN (1-394): 1.71e-133: 391: 44.88		CDK7_HUMAN (2-298): 9.86e-124: 359: 44.00
+	At
		663870 CCB12_ARATH (3-394): 4.47e-110: 332: 28.76		CDKA1_ARATH (1-289): 3.08e-144: 408: 68.62
+	At
		1180593 CCB12_ARATH (3-394): 4.47e-110: 332: 28.76		CKB12_ARATH (1-291): 1.58e-132: 380: 56.31
+	At
		1184282 CCB12_ARATH (3-394): 4.47e-110: 332: 28.76		CKB21_ARATH (1-294): 5.87e-131: 376: 54.13
+	At
		1184283 CCB12_ARATH (3-394): 4.47e-110: 332: 28.76		CKB22_ARATH (1-294): 2.69e-130: 374: 55.78
+	At
		683025 CCB24_ARATH (19-387): 2.17e-111: 334: 30.65		CKB11_ARATH (1-291): 1.3e-124: 359: 56.03
+	At
		682992 CCB12_ARATH (3-394): 4.47e-110: 332: 28.76		CKB11_ARATH (1-291): 1.3e-124: 359: 56.03