HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: MOB1B (Q7L9L4)
MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A)
Gene: MOB1B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.760

Property	Details
Experiments	34079125, 36736316, 16674920, 18328708, 24366813, 28514442, 33961781, 37536630, 19739119, 24255178
Identification Methods	proximity labelling technology, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0035329 - hippo signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 216
+	Hs
		325891 LATS1_HUMAN (1-1130): 0: 934: 100.00		MOB1A_HUMAN (1-216): 5.45e-119: 338: 95.83
+	Hs
		325791 LATS1_HUMAN (1-1130): 0: 934: 100.00		MOB3B_HUMAN (5-212): 3.49e-108: 311: 53.59
+	Hs
		325844 LATS1_HUMAN (1-1130): 0: 934: 100.00		MOB3A_HUMAN (5-212): 3.88e-106: 306: 53.11
+	Hs
		325785 LATS1_HUMAN (1-1130): 0: 934: 100.00		MOB3C_HUMAN (5-212): 1.7e-105: 304: 48.80
+	Hs
		325784 LATS1_HUMAN (1-1130): 0: 934: 100.00		MOB2_HUMAN (1-213): 4e-86: 256: 40.85
+	Hs
		325949 LATS1_HUMAN (1-1130): 0: 934: 100.00		PHOCN_HUMAN (6-201): 3.76e-67: 207: 19.60
+	Hs
		1185503 LATS2_HUMAN (13-1121): 0: 751: 49.61		MOB1B_HUMAN (1-216): 4.62e-119: 338: 100.00
+	Hs
		1333705 LATS2_HUMAN (13-1121): 0: 751: 49.61		MOB1A_HUMAN (1-216): 5.45e-119: 338: 95.83
+	Hs
		1198336 LATS2_HUMAN (13-1121): 0: 751: 49.61		MOB3B_HUMAN (5-212): 3.49e-108: 311: 53.59
+	Hs
		1285989 LATS2_HUMAN (13-1121): 0: 751: 49.61		MOB3A_HUMAN (5-212): 3.88e-106: 306: 53.11
+	Hs
		1174306 LATS2_HUMAN (13-1121): 0: 751: 49.61		MOB3C_HUMAN (5-212): 1.7e-105: 304: 48.80
+	Hs
		1344983 LATS2_HUMAN (13-1121): 0: 751: 49.61		PHOCN_HUMAN (6-201): 3.76e-67: 207: 19.60
+	Hs
		1185506 ST38L_HUMAN (627-1089): 2.37e-167: 503: 40.82		MOB1B_HUMAN (1-216): 4.62e-119: 338: 100.00
+	Hs
		1333714 ST38L_HUMAN (627-1089): 2.37e-167: 503: 40.82		MOB1A_HUMAN (1-216): 5.45e-119: 338: 95.83
+	Ca
		1124241 CBK1_CANAL (448-1091): 9.16e-168: 514: 32.18		MOB2_CANAL (25-216): 4.12e-88: 263: 41.15
+	Sc
		774485 CBK1_YEAST (397-1091): 2.99e-167: 514: 30.07		MOB1_YEAST (7-214): 2.04e-84: 254: 49.05
+	Sp
		140739 ORB6_SCHPO (630-1086): 3.84e-167: 503: 39.39		MOB2_SCHPO (14-215): 2.45e-87: 259: 39.60
+	Sc
		797131 CBK1_YEAST (397-1091): 2.99e-167: 514: 30.07		MOB2_YEAST (17-216): 3.01e-82: 247: 37.50
+	Hs
		1174241 ST38L_HUMAN (627-1089): 2.37e-167: 503: 40.82		MOB2_HUMAN (1-213): 4e-86: 256: 40.85
+	Hs
		1069621 STK38_HUMAN (622-1089): 5.96e-165: 497: 40.17		MOB2_HUMAN (1-213): 4e-86: 256: 40.85