HitPredict

Interactor 1: VAMP5 (O95183)
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Gene: VAMP5

Interactor 2: STX1A (Q16623)
Syntaxin-1A (Neuron-specific antigen HPC-1)
Gene: STX1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	32296183, 24722188, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin, Synaptobrevin~Syntaxin
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 116 Hs			1 288
+	Hs
		328656 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		STX1B_HUMAN (1-288): 5.22e-85: 258: 83.33
+	Hs
		328635 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		STX2_HUMAN (1-288): 6.63e-82: 250: 63.89
+	Dm
		1174524 Q7JYX5_DROME (4-96): 8e-33: 115: 31.18		STX1A_DROME (2-287): 2.61e-75: 233: 69.90
+	Hs
		328768 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		X5D7S1_HUMAN (1-286): 4.46e-66: 208: 85.66
+	Hs
		328664 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		STX3_HUMAN (1-288): 2.82e-64: 205: 62.41
+	Hs
		328661 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		STX4_HUMAN (1-287): 1.23e-63: 203: 43.58
+	Dm
		1174432 Q7JYX5_DROME (4-96): 8e-33: 115: 31.18		STX5_DROME (2-268): 2.16e-51: 176: 16.61
+	At
		1457227 VA721_ARATH (5-92): 6.51e-31: 110: 26.14		SY122_ARATH (25-266): 1.05e-53: 179: 23.20
+	Hs
		328692 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		STX12_HUMAN (26-271): 2.33e-51: 171: 24.50
+	Dm
		1263444 Q7JYX5_DROME (4-96): 8e-33: 115: 31.18		STX4_DROME (27-267): 6.26e-51: 172: 24.48
+	At
		1355121 VA721_ARATH (5-92): 6.51e-31: 110: 26.14		SY132_ARATH (13-266): 1.34e-52: 175: 23.49
+	Hs
		189356 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		STX7_HUMAN (37-286): 7.02e-50: 167: 25.30
+	At
		265751 VA721_ARATH (5-92): 6.51e-31: 110: 26.14		SYP41_ARATH (29-287): 3.71e-52: 175: 20.76
+	Hs
		160855 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		STX16_HUMAN (15-264): 1.37e-48: 165: 22.53
+	At
		1457166 VA721_ARATH (5-92): 6.51e-31: 110: 26.14		SYP43_ARATH (10-287): 2.86e-51: 172: 18.31
+	At
		1457275 VA721_ARATH (5-92): 6.51e-31: 110: 26.14		SYP42_ARATH (30-287): 2.79e-51: 172: 21.59
+	At
		1192502 VA721_ARATH (5-92): 6.51e-31: 110: 26.14		SY111_ARATH (2-266): 6.8e-51: 171: 22.88
+	At
		1020603 VA713_ARATH (4-91): 1.92e-32: 114: 22.73		SYP22_ARATH (14-272): 1.29e-48: 164: 18.89
+	At
		1020601 VA714_ARATH (4-95): 2.98e-31: 111: 23.66		SYP22_ARATH (14-272): 1.29e-48: 164: 18.89
+	At
		1020624 VA721_ARATH (5-92): 6.51e-31: 110: 26.14		SYP22_ARATH (14-272): 1.29e-48: 164: 18.89