HitPredict

Interactor 1: VAMP5 (O95183)
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Gene: VAMP5

Interactor 2: X5D7S1 (X5D7S1)
Syntaxin-1A
Gene: STX1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	24722188
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin, Synaptobrevin~Syntaxin
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 116 Hs			1 248
+	Hs
		328672 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		STX1A_HUMAN (1-245): 2.17e-53: 175: 85.61
+	Hs
		328656 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		STX1B_HUMAN (1-246): 5.02e-53: 174: 69.93
+	Hs
		328635 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		STX2_HUMAN (1-246): 2.86e-51: 170: 56.29
+	Dm
		1174524 Q7JYX5_DROME (4-96): 8e-33: 115: 31.18		STX1A_DROME (2-243): 1.2e-49: 166: 56.69
+	Hs
		189356 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		STX7_HUMAN (6-245): 7.89e-46: 155: 20.00
+	Hs
		328692 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		STX12_HUMAN (6-231): 9.61e-44: 150: 20.18
+	At
		1020603 VA713_ARATH (4-91): 1.92e-32: 114: 22.73		SYP22_ARATH (7-232): 1.43e-44: 152: 16.67
+	At
		1492011 VA721_ARATH (5-92): 6.51e-31: 110: 26.14		SY121_ARATH (3-226): 2.53e-44: 154: 20.78
+	At
		1020601 VA714_ARATH (4-95): 2.98e-31: 111: 23.66		SYP22_ARATH (7-232): 1.43e-44: 152: 16.67
+	At
		1020624 VA721_ARATH (5-92): 6.51e-31: 110: 26.14		SYP22_ARATH (7-232): 1.43e-44: 152: 16.67
+	At
		1457227 VA721_ARATH (5-92): 6.51e-31: 110: 26.14		SY122_ARATH (9-226): 4.14e-42: 148: 21.62
+	Hs
		328661 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		STX4_HUMAN (1-246): 7.38e-39: 138: 38.44
+	Hs
		328664 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		STX3_HUMAN (1-224): 1.72e-36: 132: 55.30
+	At
		1457275 VA721_ARATH (5-92): 6.51e-31: 110: 26.14		SYP42_ARATH (1-243): 9.51e-39: 139: 17.21
+	Hs
		160855 VAMP5_HUMAN (1-116): 6.16e-35: 118: 100.00		STX16_HUMAN (1-224): 6.84e-35: 128: 21.24
+	At
		265751 VA721_ARATH (5-92): 6.51e-31: 110: 26.14		SYP41_ARATH (2-243): 1.54e-37: 135: 16.53
+	At
		1457166 VA721_ARATH (5-92): 6.51e-31: 110: 26.14		SYP43_ARATH (2-243): 5.78e-36: 131: 16.13
+	At
		1355121 VA721_ARATH (5-92): 6.51e-31: 110: 26.14		SY132_ARATH (35-226): 3.33e-35: 129: 25.50
+	At
		1192502 VA721_ARATH (5-92): 6.51e-31: 110: 26.14		SY111_ARATH (17-226): 7.79e-35: 128: 22.22
+	Dm
		1263444 Q7JYX5_DROME (4-96): 8e-33: 115: 31.18		STX4_DROME (99-227): 2.86e-31: 119: 29.46