HitPredict

Interactor 1: O96989 (O96989)
CDC45L (Cell division cycle 45) (EG:BACR7A4.11 protein) (LD35753p)
Gene: Cdc45

Interactor 2: MCM6 (Q9V461)
DNA replication licensing factor Mcm6 (DmMCM6) (EC 3.6.4.12)
Gene: MCM6

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	16798881, 20122406
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CDC45~MCM_lid, CDC45~MCM_N, CDC45~MCM_OB
Common GO terms	GO:0000727 - double-strand break repair via break-induced replication GO:0003697 - single-stranded DNA binding GO:0005634 - nucleus GO:0006260 - DNA replication GO:0006270 - DNA replication initiation and 2 others more... GO:0051301 - cell division GO:0071162 - CMG complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 575 Dm			1 817
+	Hs
		264202 CDC45_HUMAN (1-575): 0: 780: 38.42		MCM6_HUMAN (1-817): 0: 805: 62.47
+	Hs
		264176 CDC45_HUMAN (1-575): 0: 780: 38.42		MCM4_HUMAN (4-745): 0: 662: 30.32
+	Hs
		264189 CDC45_HUMAN (1-575): 0: 780: 38.42		MCM2_HUMAN (2-721): 0: 661: 27.75
+	Hs
		264177 CDC45_HUMAN (1-575): 0: 780: 38.42		MCM5_HUMAN (4-731): 0: 654: 27.25
+	Hs
		264178 CDC45_HUMAN (1-575): 0: 780: 38.42		MCM7_HUMAN (22-647): 0: 643: 29.19
+	Dm
		332394 O96989_DROME (1-575): 0: 747: 100.00		MCM2_DROME (2-757): 0: 661: 27.00
+	Hs
		264171 CDC45_HUMAN (1-575): 0: 780: 38.42		MCM3_HUMAN (8-783): 0: 622: 25.41
+	Dm
		332395 O96989_DROME (1-575): 0: 747: 100.00		MCM4_DROME (3-742): 0: 646: 28.12
+	Dm
		332400 O96989_DROME (1-575): 0: 747: 100.00		MCM5_DROME (4-731): 0: 629: 28.42
+	Dm
		332411 O96989_DROME (1-575): 0: 747: 100.00		MCM3_DROME (6-783): 0: 616: 24.27
+	Sp
		251153 CDC45_SCHPO (16-571): 0: 599: 27.48		MCM6_SCHPO (4-817): 0: 714: 41.25
+	Sc
		859026 CDC45_YEAST (17-572): 0: 563: 24.17		MCM6_YEAST (11-816): 0: 708: 37.75
+	Sp
		251151 CDC45_SCHPO (16-571): 0: 599: 27.48		MCM3_SCHPO (10-705): 0: 651: 28.74
+	Sp
		251152 CDC45_SCHPO (16-571): 0: 599: 27.48		MCM2_SCHPO (2-667): 0: 633: 29.36
+	Sc
		667899 CDC45_YEAST (17-572): 0: 563: 24.17		MCM5_YEAST (14-655): 0: 666: 30.54
+	Sc
		675563 CDC45_YEAST (17-572): 0: 563: 24.17		MCM4_YEAST (14-750): 0: 621: 28.83
+	Sp
		251147 CDC45_SCHPO (16-571): 0: 599: 27.48		MCM7_SCHPO (113-647): 2.01e-93: 311: 36.38
+	Sc
		744795 CDC45_YEAST (17-572): 0: 563: 24.17		MCM7_YEAST (2-662): 1.34e-84: 289: 33.33