HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PKHA7 (Q6IQ23)
Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7)
Gene: PLEKHA7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28065597
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0030054 - cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1121
+	Hs
		338998 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PKHA5_HUMAN (11-1074): 3.5e-95: 330: 29.45
+	Hs
		339005 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SMUF1_HUMAN (4-213): 3.11e-48: 187: 18.58
+	Hs
		338999 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SMUF2_HUMAN (3-213): 6.3e-48: 185: 18.18
+	Hs
		338191 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19
+	Hs
		338764 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CNKR2_HUMAN (119-516): 1.33e-45: 181: 17.65
+	Hs
		338861 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NED4L_HUMAN (59-486): 2.54e-26: 118: 12.47
+	Hs
		338840 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITCH_HUMAN (40-305): 7.41e-17: 88.1: 14.49
+	Hs
		338105 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NEDD4_HUMAN (11-95): 1.03e-15: 84.6: 24.17
+	Hs
		338959 EGFR_HUMAN (1-1210): 0: 1241: 100.00		WWP1_HUMAN (42-252): 1.75e-13: 77.4: 17.05
+	Hs
		383984 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		SMUF2_HUMAN (3-213): 6.3e-48: 185: 18.18
+	Hs
		1071023 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		WWOX_HUMAN (9-115): 8.02e-20: 95.4: 29.91
+	Hs
		1070998 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		ITCH_HUMAN (40-305): 7.41e-17: 88.1: 14.49
+	Hs
		808132 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		NEDD4_HUMAN (11-95): 1.03e-15: 84.6: 24.17
+	Hs
		1071010 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		WWP1_HUMAN (42-252): 1.75e-13: 77.4: 17.05
+	Hs
		601981 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		NED4L_HUMAN (59-486): 2.54e-26: 118: 12.47
+	Hs
		601974 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		ITCH_HUMAN (40-305): 7.41e-17: 88.1: 14.49
+	Hs
		601847 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		NEDD4_HUMAN (11-95): 1.03e-15: 84.6: 24.17
+	Hs
		665661 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		PKHA5_HUMAN (11-1074): 3.5e-95: 330: 29.45
+	Hs
		665569 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		AFAD_HUMAN (329-1063): 1.33e-45: 182: 11.19
+	Hs
		434157 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		NEDD4_HUMAN (11-95): 1.03e-15: 84.6: 24.17