HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PFKAP (Q01813)
ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase)
Gene: PFKP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	29677490, 23956138, 24797263
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016020 - membrane GO:0045296 - cadherin binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 784
+	Hs
		337798 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PFKAM_HUMAN (13-779): 0: 1030: 71.78
+	Hs
		383748 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		337899 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03
+	Hs
		411357 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		PFKAP_HUMAN (1-784): 0: 1093: 100.00
+	Hs
		411276 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		PFKAM_HUMAN (13-779): 0: 1030: 71.78
+	Hs
		383594 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PFKAL_HUMAN (396-739): 1.72e-65: 234: 27.03
+	Hs
		435613 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		PFKAP_HUMAN (1-784): 0: 1093: 100.00