HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PTN23 (Q9H3S7)
Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14)
Gene: PTPN23

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34761192, 23477725
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005768 - endosome GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1636
+	Hs
		338749 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PDC6I_HUMAN (9-871): 7.58e-165: 523: 22.24
+	Hs
		337903 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN1_HUMAN (1206-1566): 2.6e-121: 390: 26.39
+	Hs
		337987 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN6_HUMAN (1159-1472): 7.88e-118: 386: 23.96
+	Hs
		338901 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN18_HUMAN (1189-1596): 2.39e-115: 374: 25.64
+	Hs
		337897 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN2_HUMAN (1174-1506): 2.24e-115: 372: 27.55
+	Hs
		337909 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRA_HUMAN (1205-1455): 7.92e-89: 310: 30.59
+	Hs
		337941 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRD_HUMAN (1204-1453): 7.9e-82: 301: 30.71
+	Hs
		337831 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRF_HUMAN (1204-1453): 3.45e-77: 286: 29.92
+	Hs
		337942 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRE_HUMAN (1208-1453): 1.74e-80: 283: 32.55
+	Hs
		665895 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTN6_HUMAN (1159-1472): 7.88e-118: 386: 23.96
+	Hs
		146919 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRT_HUMAN (1177-1455): 1.05e-54: 212: 22.73
+	Hs
		338458 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRK_HUMAN (1178-1455): 1.28e-50: 199: 22.54
+	Hs
		338787 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRU_HUMAN (1175-1454): 3.8e-48: 191: 23.69
+	Hs
		337943 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRG_HUMAN (1209-1470): 7.88e-39: 161: 26.18
+	Mm
		719299 EGFR_MOUSE (1-1210): 0: 1258: 90.35		PTN11_MOUSE (1195-1459): 4.76e-30: 129: 30.63
+	Hs
		339009 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRH_HUMAN (1206-1458): 4.47e-31: 135: 34.88
+	Hs
		337940 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRB_HUMAN (1220-1451): 1.04e-29: 131: 33.75
+	Hs
		338317 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN11_HUMAN (1195-1459): 5.34e-30: 129: 30.63
+	Hs
		146927 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTPRT_HUMAN (1177-1455): 1.05e-54: 212: 22.73
+	Hs
		985960 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTN11_HUMAN (1195-1459): 5.34e-30: 129: 30.63