HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: TFAM (Q00059)
Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2)
Gene: TFAM

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	29467282, 35013218, 21150319
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0032991 - protein-containing complex GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 246
+	Hs
		347960 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		HM20A_HUMAN (45-146): 3.64e-24: 100: 19.61
+	Hs
		346139 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SOX3_HUMAN (124-224): 6.52e-22: 95.6: 18.10
+	Hs
		346609 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SOX4_HUMAN (148-229): 1.28e-18: 86: 22.09
+	Hs
		345975 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		HMGB2_HUMAN (48-142): 4.13e-15: 73.3: 16.84
+	Hs
		345751 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		HMGB1_HUMAN (27-128): 2.21e-14: 71.7: 15.69
+	Hs
		345860 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		UBF1_HUMAN (51-214): 4.22e-11: 64.4: 20.46
+	Hs
		297442 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		TOX4_HUMAN (151-222): 3.34e-09: 58.7: 21.05
+	Hs
		379296 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00
+	Hs
		379899 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		HM20A_HUMAN (45-146): 3.64e-24: 100: 19.61
+	Hs
		175737 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		HMGB3_HUMAN (46-136): 1.77e-17: 79.8: 21.98
+	Hs
		379037 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		HMGB2_HUMAN (48-142): 4.13e-15: 73.3: 16.84
+	Hs
		378934 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		HMGB1_HUMAN (27-128): 2.21e-14: 71.7: 15.69
+	Hs
		378995 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		UBF1_HUMAN (51-214): 4.22e-11: 64.4: 20.46
+	Mm
		927934 SRBP1_MOUSE (172-453): 4.45e-35: 140: 16.61		HMGB1_MOUSE (27-128): 2.21e-14: 71.7: 15.69
+	Hs
		898205 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		HM20A_HUMAN (45-146): 3.64e-24: 100: 19.61
+	Hs
		989545 MNT_HUMAN (274-452): 2.36e-24: 107: 21.11		SOX4_HUMAN (148-229): 1.28e-18: 86: 22.09