HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: SKP2 (Q13309)
S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)
Gene: SKP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.745

Property	Details
Experiments	26038816, 35260179, 12769844, 12963825, 17157259, 23277542, 24259667
Identification Methods	affinity chromatography technology, pull down, protein complementation assay, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 424
+	Hs
		347319 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		FXL16_HUMAN (34-378): 2.42e-47: 170: 19.95
+	Hs
		348287 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		KDM2A_HUMAN (77-410): 3.55e-42: 161: 17.06
+	Hs
		379364 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SKP2_HUMAN (1-424): 3e-94: 291: 100.00
+	Hs
		347381 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		KDM2B_HUMAN (233-423): 5.06e-11: 67.1: 18.81
+	Hs
		1218688 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		KDM2B_HUMAN (233-423): 5.06e-11: 67.1: 18.81