HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: PPARG (P37231)
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
Gene: PPARG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	20195357
Identification Methods	display technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 505
+	Hs
		396501 MINK1_HUMAN (1-1239): 0: 1130: 59.29		ESR1_HUMAN (1-501): 9.13e-112: 345: 19.28
+	Hs
		1326423 MINK1_HUMAN (1-1239): 0: 1130: 59.29		ESR2_HUMAN (23-502): 1.8e-98: 308: 18.70
+	Hs
		789485 AAPK1_HUMAN (8-555): 2.04e-123: 394: 16.85		PPARG_HUMAN (1-505): 2.48e-165: 479: 100.00
+	Hs
		1231943 MRCKG_HUMAN (13-974): 4.84e-143: 473: 17.19		ESR2_HUMAN (23-502): 1.8e-98: 308: 18.70
+	Hs
		395530 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		ESR1_HUMAN (1-501): 9.13e-112: 345: 19.28
+	Hs
		156822 CTRO_HUMAN (14-616): 2.47e-117: 405: 22.33		ESR1_HUMAN (1-501): 9.13e-112: 345: 19.28
+	Hs
		395573 AKT2_HUMAN (2-354): 3.96e-124: 393: 21.98		ESR1_HUMAN (1-501): 9.13e-112: 345: 19.28
+	Hs
		404556 SIK3_HUMAN (7-915): 2.85e-126: 423: 14.35		GCR_HUMAN (18-503): 2e-98: 315: 17.85
+	Hs
		728183 AKT1_HUMAN (2-354): 1.3e-122: 389: 20.82		PPARD_HUMAN (99-505): 1.48e-115: 349: 60.29
+	Hs
		395572 AKT1_HUMAN (2-354): 1.3e-122: 389: 20.82		ESR1_HUMAN (1-501): 9.13e-112: 345: 19.28
+	Hs
		396396 MARK2_HUMAN (19-772): 2.97e-118: 388: 16.14		ESR1_HUMAN (1-501): 9.13e-112: 345: 19.28
+	Hs
		692108 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		ESR2_HUMAN (23-502): 1.8e-98: 308: 18.70
+	Hs
		157694 CTRO_HUMAN (14-616): 2.47e-117: 405: 22.33		ESR2_HUMAN (23-502): 1.8e-98: 308: 18.70
+	Hs
		520522 AKT1_HUMAN (2-354): 1.3e-122: 389: 20.82		RARA_HUMAN (45-503): 3.9e-102: 316: 25.22
+	Hs
		403859 AKT1_HUMAN (2-354): 1.3e-122: 389: 20.82		GCR_HUMAN (18-503): 2e-98: 315: 17.85
+	Hs
		665068 AKT2_HUMAN (2-354): 3.96e-124: 393: 21.98		COT2_HUMAN (70-501): 4e-101: 311: 22.35
+	Hs
		652453 AKT1_HUMAN (2-354): 1.3e-122: 389: 20.82		NR4A1_HUMAN (4-503): 3.34e-99: 312: 20.83
+	Hs
		665067 AKT1_HUMAN (2-354): 1.3e-122: 389: 20.82		COT2_HUMAN (70-501): 4e-101: 311: 22.35
+	Hs
		1270485 MARK2_HUMAN (19-772): 2.97e-118: 388: 16.14		ESR2_HUMAN (23-502): 1.8e-98: 308: 18.70
+	Hs
		1361081 MYO3B_HUMAN (13-330): 3.67e-112: 384: 47.56		ESR2_HUMAN (23-502): 1.8e-98: 308: 18.70