HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: STYK1 (Q6J9G0)
Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1)
Gene: STYK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 422
+	Hs
		348044 M4K4_HUMAN (1-1239): 0: 1238: 100.00		FGFR1_HUMAN (11-417): 5.09e-126: 385: 24.20
+	Hs
		348059 M4K4_HUMAN (1-1239): 0: 1238: 100.00		EPHA2_HUMAN (46-411): 2.84e-121: 377: 21.95
+	Hs
		348060 M4K4_HUMAN (1-1239): 0: 1238: 100.00		EPHB2_HUMAN (5-414): 9.29e-121: 377: 18.55
+	Hs
		348080 M4K4_HUMAN (1-1239): 0: 1238: 100.00		EPHA5_HUMAN (2-408): 3.96e-121: 377: 20.33
+	Hs
		348128 M4K4_HUMAN (1-1239): 0: 1238: 100.00		EPHA7_HUMAN (36-414): 2.45e-120: 375: 19.37
+	Hs
		348081 M4K4_HUMAN (1-1239): 0: 1238: 100.00		EPHA4_HUMAN (42-417): 6.77e-119: 371: 18.73
+	Hs
		348056 M4K4_HUMAN (1-1239): 0: 1238: 100.00		FGFR4_HUMAN (80-392): 2.33e-119: 367: 28.79
+	Hs
		541588 MINK1_HUMAN (1-1239): 0: 1130: 59.29		FGFR1_HUMAN (11-417): 5.09e-126: 385: 24.20
+	Hs
		710363 MINK1_HUMAN (1-1239): 0: 1130: 59.29		EPHA2_HUMAN (46-411): 2.84e-121: 377: 21.95
+	Hs
		931869 MINK1_HUMAN (1-1239): 0: 1130: 59.29		EPHA5_HUMAN (2-408): 3.96e-121: 377: 20.33
+	Hs
		1147376 MINK1_HUMAN (1-1239): 0: 1130: 59.29		EPHA7_HUMAN (36-414): 2.45e-120: 375: 19.37
+	Hs
		541750 TNIK_HUMAN (1-1239): 0: 1115: 60.45		FGFR1_HUMAN (11-417): 5.09e-126: 385: 24.20
+	Hs
		710556 TNIK_HUMAN (1-1239): 0: 1115: 60.45		EPHA2_HUMAN (46-411): 2.84e-121: 377: 21.95
+	Hs
		710914 TNIK_HUMAN (1-1239): 0: 1115: 60.45		EPHB2_HUMAN (5-414): 9.29e-121: 377: 18.55
+	Hs
		931911 TNIK_HUMAN (1-1239): 0: 1115: 60.45		EPHA5_HUMAN (2-408): 3.96e-121: 377: 20.33
+	Hs
		1147461 TNIK_HUMAN (1-1239): 0: 1115: 60.45		EPHA7_HUMAN (36-414): 2.45e-120: 375: 19.37
+	Hs
		648726 TNIK_HUMAN (1-1239): 0: 1115: 60.45		FGFR4_HUMAN (80-392): 2.33e-119: 367: 28.79
+	Hs
		1235348 TNIK_HUMAN (1-1239): 0: 1115: 60.45		STYK1_HUMAN (1-422): 2.29e-123: 366: 100.00
+	Hs
		541351 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		FGFR1_HUMAN (11-417): 5.09e-126: 385: 24.20
+	Hs
		834240 MAST1_HUMAN (3-947): 3.46e-134: 449: 14.58		CSK_HUMAN (144-386): 2.32e-36: 140: 36.89