HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: PLCD1 (P51178)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-1) (Phospholipase C-III) (PLC-III) (Phospholipase C-delta-1) (PLC-delta-1)
Gene: PLCD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30442766
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH_12~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 756
+	Hs
		349987 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PLCD1_HUMAN (1-756): 0: 888: 100.00
+	Hs
		349202 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		PLCD1_HUMAN (1-756): 0: 888: 100.00
+	Hs
		350690 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PLCL2_HUMAN (18-756): 0: 801: 36.95
+	Hs
		349735 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		PLCL2_HUMAN (18-756): 0: 801: 36.95
+	Hs
		350581 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PLCB1_HUMAN (9-756): 0: 708: 29.07
+	Hs
		1070411 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		PLCB1_HUMAN (9-756): 0: 708: 29.07
+	Hs
		350087 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PLCB3_HUMAN (9-756): 0: 705: 28.07
+	Hs
		914080 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		PLCB4_HUMAN (16-755): 0: 722: 29.80
+	Hs
		348942 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		PLCB1_HUMAN (9-756): 0: 708: 29.07
+	Hs
		349665 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		PLCB1_HUMAN (9-756): 0: 708: 29.07
+	Hs
		349256 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		PLCB3_HUMAN (9-756): 0: 705: 28.07
+	Hs
		895288 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		PLCB1_HUMAN (9-756): 0: 708: 29.07
+	Hs
		350215 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PLCH1_HUMAN (438-756): 1.24e-73: 263: 37.77
+	Hs
		1070221 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		PLCH1_HUMAN (438-756): 1.24e-73: 263: 37.77
+	Hs
		253284 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		PLCH2_HUMAN (463-756): 9.6e-77: 272: 39.26
+	Hs
		348700 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		PLCH1_HUMAN (438-756): 1.24e-73: 263: 37.77
+	Hs
		580971 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		PLCG1_HUMAN (478-754): 4.91e-75: 266: 36.56
+	Hs
		895108 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		PLCH1_HUMAN (438-756): 1.24e-73: 263: 37.77
+	Hs
		348976 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		PLCE1_HUMAN (453-751): 2.37e-63: 233: 27.07
+	Hs
		349695 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		PLCE1_HUMAN (453-751): 2.37e-63: 233: 27.07