Protein: TRXR2
Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Selenoprotein Z) (SelZ) (TR-beta) (Thioredoxin reductase TR3)

Gene: TRXR2, TXNRD2
Organism: Homo sapiens
Interactions: 29
UniProt ID: Q9NNW7

Gene Ontology (top 5):
GO:0000305 - response to oxygen radical
GO:0004791 - thioredoxin-disulfide reductase (NADPH) activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1164377

TRXR1
Thioredoxin reductase 1, cytoplasmic

2

15

High-throughput

0.789

High

869247

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.656

High

1445766

TRXR2
Thioredoxin reductase 2, mitochondrial

1

16

High-throughput

0.618

High

1382805

PLPL2
Patatin-like phospholipase domain-containing protein 2

2

0

High-throughput

0.602

High

1402972

CP2S1
Cytochrome P450 2S1

2

0

High-throughput

0.602

High

1445771

PPR3C
Protein phosphatase 1 regulatory subunit 3C

2

0

High-throughput

0.585

High

610479

PRS6A
26S proteasome regulatory subunit 6A

1

10

Small-scale

0.573

High

278432

NCOR1
Nuclear receptor corepressor 1

2

0

Small-scale

0.569

High

564403

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

349709

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

1

2

High-throughput

0.536

High

1130602

NCOA6
Nuclear receptor coactivator 6

1

2

Small-scale

0.527

High

1310435

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1413677

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

1

0

High-throughput

0.513

High

1445768

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

High-throughput

0.513

High

1150410

NCOA2
Nuclear receptor coactivator 2

1

1

Small-scale

0.481

High

1255645

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1445769

XPO7
Exportin-7

1

0

High-throughput

0.458

High

142421

PEX7
Peroxisomal targeting signal 2 receptor

1

5

High-throughput

0.445

High

1445770

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.445

High

1399139

CF418
Cilia- and flagella-associated protein 418

1

0

Small-scale

0.438

High

1103395

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.437

High

1445772

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.437

High

653586

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1245362

FOXR2
Forkhead box protein R2

3

0

High-throughput

0.347

High

744688

TF2H1
General transcription factor IIH subunit 1

1

0

Small-scale

0.299

High

1445767

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

1

0

High-throughput

0.279

Low

298088

SPF27
Pre-mRNA-splicing factor SPF27

1

0

Small-scale

0.261

Low

284885

TADA3
Transcriptional adapter 3

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025