HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.996

The method score is based on:

Property Details
Experiments 26721396, 10887184, 14654780, 15031288, 14724584, 16573649, 22605333, 12620389, 30481304, 28205554, 10882715, 16214894, 16916524, 8530446, 9150145, 9154803, 30639242, 10783161, 9523700, 10922060 and 27 others

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Identification Methods affinity chromatography technology, pull down, two hybrid, enzymatic study, fluorescent resonance energy transfer, proximity labelling technology, protein complementation assay, x-ray crystallography, molecular sieving, anti bait coimmunoprecipitation and 2 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains C1_1~Ras, Pkinase~Ras, RBD~Ras
Common GO terms GO:0000165 - MAPK cascade
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0005886 - plasma membrane
and 8 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 189
Hs

1 648
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024