HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: AMOT (Q4VCS5)
Angiomotin
Gene: AMOT

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.728

Property	Details
Experiments	24366813, 30266805, 32292505, 34079125, 24255178, 24101513
Identification Methods	affinity chromatography technology, proximity labelling technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008104 - intracellular protein localization GO:0035329 - hippo signaling GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 1084
+	Hs
		349150 LATS1_HUMAN (1-1130): 0: 925: 100.00		AMOL1_HUMAN (1-912): 1.21e-43: 174: 44.28
+	Hs
		1197101 LATS2_HUMAN (13-1121): 0: 742: 49.52		AMOT_HUMAN (1-1084): 2.95e-100: 343: 100.00
+	Hs
		348952 LATS1_HUMAN (1-1130): 0: 925: 100.00		MYH7_HUMAN (349-838): 2.02e-18: 93.8: 10.02
+	Hs
		348954 LATS1_HUMAN (1-1130): 0: 925: 100.00		MYH6_HUMAN (251-882): 4.42e-17: 89.2: 9.75
+	Hs
		348951 LATS1_HUMAN (1-1130): 0: 925: 100.00		MYH1_HUMAN (144-882): 1.6e-15: 84.2: 8.45
+	Hs
		348955 LATS1_HUMAN (1-1130): 0: 925: 100.00		MYH8_HUMAN (432-916): 2.16e-13: 77.3: 11.41
+	Hs
		349307 LATS1_HUMAN (1-1130): 0: 925: 100.00		MYH4_HUMAN (432-920): 1.6e-12: 74.2: 10.71
+	Hs
		349288 LATS1_HUMAN (1-1130): 0: 925: 100.00		MYH13_HUMAN (435-755): 4.67e-12: 72.7: 20.63
+	Hs
		349287 LATS1_HUMAN (1-1130): 0: 925: 100.00		MYH2_HUMAN (511-905): 1.48e-10: 68.1: 10.47
+	Hs
		1314106 LATS2_HUMAN (13-1121): 0: 742: 49.52		AMOL1_HUMAN (1-912): 1.21e-43: 174: 44.28
+	Hs
		1448721 LATS2_HUMAN (13-1121): 0: 742: 49.52		AMOL2_HUMAN (296-902): 1.23e-28: 125: 40.92
+	Hs
		773091 ST38L_HUMAN (627-1089): 1.01e-161: 489: 40.82		MYH9_HUMAN (358-774): 8.67e-19: 94.9: 14.38
+	Hs
		728066 AKT1_HUMAN (595-1079): 1.92e-140: 434: 24.60		MYH9_HUMAN (358-774): 8.67e-19: 94.9: 14.38
+	Hs
		605577 KAPCA_HUMAN (661-1058): 1.57e-137: 421: 31.59		MYH9_HUMAN (358-774): 8.67e-19: 94.9: 14.38
+	Hs
		728227 AKT1_HUMAN (595-1079): 1.92e-140: 434: 24.60		DCTN1_HUMAN (510-863): 1.71e-09: 64.5: 14.85
+	Hs
		562995 KAPCB_HUMAN (661-1055): 6.64e-133: 409: 31.58		MYH6_HUMAN (251-882): 4.42e-17: 89.2: 9.75
+	Hs
		605578 KAPCA_HUMAN (661-1058): 1.57e-137: 421: 31.59		MYH10_HUMAN (389-818): 6.65e-13: 75.8: 18.35
+	Hs
		556840 KAPCB_HUMAN (661-1055): 6.64e-133: 409: 31.58		MYH1_HUMAN (144-882): 1.6e-15: 84.2: 8.45
+	Hs
		651743 KAPCB_HUMAN (661-1055): 6.64e-133: 409: 31.58		MYH4_HUMAN (432-920): 1.6e-12: 74.2: 10.71
+	Hs
		651734 KAPCB_HUMAN (661-1055): 6.64e-133: 409: 31.58		MYH2_HUMAN (511-905): 1.48e-10: 68.1: 10.47