HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: PLCB3 (Q01970)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3)
Gene: PLCB3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH_14~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 1234
+	Hs
		350087 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCB3_HUMAN (1-1234): 0: 1137: 100.00
+	Hs
		348942 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PLCB1_HUMAN (1-1233): 0: 856: 46.43
+	Hs
		350581 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCB1_HUMAN (1-1233): 0: 856: 46.43
+	Hs
		253284 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCH2_HUMAN (11-830): 0: 876: 28.82
+	Hs
		349665 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCB1_HUMAN (1-1233): 0: 856: 46.43
+	Hs
		348700 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PLCH1_HUMAN (14-940): 0: 786: 25.48
+	Hs
		350215 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCH1_HUMAN (14-940): 0: 786: 25.48
+	Hs
		350690 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCL2_HUMAN (15-1093): 0: 754: 21.73
+	Hs
		349735 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCL2_HUMAN (15-1093): 0: 754: 21.73
+	Hs
		348580 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PLCD1_HUMAN (8-841): 0: 703: 24.59
+	Hs
		349987 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCD1_HUMAN (8-841): 0: 703: 24.59
+	Hs
		349202 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCD1_HUMAN (8-841): 0: 703: 24.59
+	Hs
		846022 RB11B_HUMAN (4-171): 1.34e-72: 219: 34.12		PLCD1_HUMAN (8-841): 0: 703: 24.59
+	Hs
		506371 RALA_HUMAN (4-168): 3.3e-59: 185: 54.22		PLCD1_HUMAN (8-841): 0: 703: 24.59
+	Hs
		348976 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PLCE1_HUMAN (153-1112): 0: 612: 21.18
+	Hs
		349695 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCE1_HUMAN (153-1112): 0: 612: 21.18
+	Hs
		919682 RAP1A_HUMAN (1-165): 3.2e-62: 192: 56.89		PLCE1_HUMAN (153-1112): 0: 612: 21.18
+	Hs
		580971 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		PLCG1_HUMAN (581-901): 1.66e-74: 273: 32.83
+	Hs
		914080 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		PLCB4_HUMAN (991-1233): 9.76e-11: 68.7: 9.20