HitPredict

Interactor 1: CBX7 (O95931)
Chromobox protein homolog 7
Gene: CBX7

Interactor 2: PCGF3 (Q3KNV8)
Polycomb group RING finger protein 3 (RING finger protein 3A)
Gene: PCGF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.911

Property	Details
Experiments	26186194, 28514442, 33961781, 21282530
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 251 Hs			1 242
+	Hs
		351372 CBX7_HUMAN (1-251): 1.06e-81: 247: 100.00		BMI1_HUMAN (3-238): 8.59e-60: 193: 33.76
+	Hs
		351373 CBX7_HUMAN (1-251): 1.06e-81: 247: 100.00		PCGF2_HUMAN (3-238): 3.05e-58: 189: 33.76
+	Hs
		351402 CBX7_HUMAN (1-251): 1.06e-81: 247: 100.00		PCGF1_HUMAN (3-238): 3.33e-45: 153: 39.17
+	Hs
		351403 CBX7_HUMAN (1-251): 1.06e-81: 247: 100.00		PCGF6_HUMAN (3-235): 5.41e-43: 150: 34.89
+	Hs
		129739 CBX4_HUMAN (1-242): 2.25e-55: 187: 33.60		PCGF3_HUMAN (1-242): 8.87e-66: 205: 100.00
+	Hs
		351393 CBX7_HUMAN (1-251): 1.06e-81: 247: 100.00		PCGF5_HUMAN (4-241): 1.49e-39: 138: 38.06
+	Hs
		129671 CBX4_HUMAN (1-242): 2.25e-55: 187: 33.60		BMI1_HUMAN (3-238): 8.59e-60: 193: 33.76
+	Hs
		351400 CBX7_HUMAN (1-251): 1.06e-81: 247: 100.00		RING2_HUMAN (2-237): 1e-35: 131: 18.00
+	Mm
		237300 CBX4_MOUSE (1-242): 9.54e-58: 194: 33.60		PCGF2_MOUSE (3-238): 7.23e-56: 183: 34.18
+	Hs
		351384 CBX7_HUMAN (1-251): 1.06e-81: 247: 100.00		RING1_HUMAN (3-172): 7.36e-35: 130: 20.81
+	Hs
		129672 CBX4_HUMAN (1-242): 2.25e-55: 187: 33.60		PCGF2_HUMAN (3-238): 3.05e-58: 189: 33.76
+	Hs
		129650 CBX4_HUMAN (1-242): 2.25e-55: 187: 33.60		RO52_HUMAN (2-241): 1.02e-46: 163: 15.56
+	Dr
		1274171 Q804D1_DANRE (1-175): 1.65e-41: 149: 35.75		BMI1B_DANRE (3-238): 2.13e-60: 194: 31.36
+	Hs
		129796 CBX4_HUMAN (1-242): 2.25e-55: 187: 33.60		PCGF1_HUMAN (3-238): 3.33e-45: 153: 39.17
+	Hs
		129801 CBX4_HUMAN (1-242): 2.25e-55: 187: 33.60		PCGF6_HUMAN (3-235): 5.41e-43: 150: 34.89
+	Hs
		129756 CBX4_HUMAN (1-242): 2.25e-55: 187: 33.60		PCGF5_HUMAN (4-241): 1.49e-39: 138: 38.06
+	Mm
		237306 CBX4_MOUSE (1-242): 9.54e-58: 194: 33.60		RING2_MOUSE (2-237): 7.77e-36: 131: 18.00
+	Hs
		129792 CBX4_HUMAN (1-242): 2.25e-55: 187: 33.60		RING2_HUMAN (2-237): 1e-35: 131: 18.00
+	Hs
		129723 CBX4_HUMAN (1-242): 2.25e-55: 187: 33.60		RING1_HUMAN (3-172): 7.36e-35: 130: 20.81
+	Mm
		1247833 Q6TKP2_MOUSE (1-198): 5.15e-41: 150: 32.29		RING2_MOUSE (2-237): 7.77e-36: 131: 18.00