Interactor 1: INS (P01308)
Insulin [Cleaved into: Insulin B chain; Insulin A chain]
Gene: INS

Interactor 2: INS (P01308)
Insulin [Cleaved into: Insulin B chain; Insulin A chain]
Gene: INS

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.978

The method score is based on:

Property Details
Experiments 32457219, 17472440, 22854022, 10508408, 23106816, 20738396, 23416304, 23510797, 8844841
Identification Methods affinity chromatography technology, x ray scattering, x-ray fiber diffraction, aggregation assay, x-ray crystallography, fluorescence technology, dynamic light scattering, molecular sieving, blue native page, nuclear magnetic resonance and 2 others

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Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Insulin~Insulin
Common GO terms GO:0000139 - Golgi membrane
GO:0001819 - positive regulation of cytokine production
GO:0002020 - protease binding
GO:0002674 - negative regulation of acute inflammatory response
GO:0005158 - insulin receptor binding
and 70 others

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Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 110
Hs

1 110
+ Ss
+ Bt

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024