HitPredict

Interactor 1: H2B1 (P02293)
Histone H2B.1 (Suppressor of Ty protein 12)
Gene: HTB1

Interactor 2: INO80 (P53115)
Chromatin-remodeling ATPase INO80 (EC 3.6.4.-) (Inositol-requiring protein 80)
Gene: INO80

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.906

Property	Details
Experiments	30120252, 24034245, 15607974, 17693258, 21179020
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 131 Sc			1 1489
+	Sc
		355948 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		INO80_YEAST (1-1489): 0: 895: 100.00
+	Sc
		356014 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		SWR1_YEAST (63-1474): 1.38e-177: 573: 21.29
+	Hs
		1018625 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		CHD3_HUMAN (1116-1487): 5.19e-83: 304: 23.71
+	Hs
		707612 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		CHD3_HUMAN (1116-1487): 5.19e-83: 304: 23.71
+	Hs
		1087449 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		CHD7_HUMAN (1162-1486): 4.59e-79: 292: 25.51
+	Hs
		229415 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		SMCA5_HUMAN (1122-1487): 3.9e-80: 289: 27.49
+	Hs
		229458 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		SMCA5_HUMAN (1122-1487): 3.9e-80: 289: 27.49
+	Hs
		229321 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		SMCA5_HUMAN (1122-1487): 3.9e-80: 289: 27.49
+	Hs
		1307128 H2B1M_HUMAN (7-128): 9.18e-47: 148: 69.36		CHD8_HUMAN (1162-1486): 1.91e-75: 280: 24.93
+	Hs
		1087418 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		CHD8_HUMAN (1162-1486): 1.91e-75: 280: 24.93
+	Hs
		846990 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		SMCA4_HUMAN (1133-1475): 1.41e-75: 279: 24.72
+	Hs
		1059648 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		CHD4_HUMAN (1157-1481): 9.65e-73: 271: 25.96
+	Hs
		1059777 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		CHD4_HUMAN (1157-1481): 9.65e-73: 271: 25.96
+	Hs
		707635 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		CHD4_HUMAN (1157-1481): 9.65e-73: 271: 25.96
+	Hs
		707647 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		CHD9_HUMAN (1162-1486): 2.18e-72: 270: 24.64
+	Hs
		658684 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		SMCA1_HUMAN (1292-1483): 8.44e-68: 251: 40.00
+	Sc
		356040 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		ISW2_YEAST (1292-1483): 1.06e-66: 249: 43.01
+	Hs
		707597 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		ERCC6_HUMAN (1215-1481): 8.07e-65: 245: 28.47
+	Sc
		355873 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		ISW1_YEAST (1314-1448): 6.51e-34: 144: 52.21
+	Hs
		1087210 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		SRCAP_HUMAN (918-1236): 2.42e-15: 84.3: 10.15