HitPredict

Interactor 1: O97111 (O97111)
LD29223p (PAR-6) (Par-6, isoform B)
Gene: par-6

Interactor 2: RAC1 (P40792)
Ras-related protein Rac1
Gene: RAC1

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	15710747
Identification Methods	two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0007298 - border follicle cell migration GO:0051491 - positive regulation of filopodium assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 351 Dm			1 192
+	Dm
		356504 O97111_DROME (1-351): 1.97e-91: 279: 100.00		CDC42_DROME (1-192): 1.24e-77: 231: 69.79
+	Hs
		988678 PAR6B_HUMAN (13-336): 7.26e-69: 222: 48.01		RAC1_HUMAN (1-192): 7.26e-85: 250: 91.67
+	Hs
		988677 PAR6G_HUMAN (1-334): 5.9e-66: 214: 46.06		RAC1_HUMAN (1-192): 7.26e-85: 250: 91.67
+	Hs
		1418672 PAR6B_HUMAN (13-336): 7.26e-69: 222: 48.01		RHOJ_HUMAN (2-190): 4.29e-80: 239: 60.32
+	Hs
		168669 CSKP_HUMAN (29-344): 8.01e-60: 208: 16.05		RAC1_HUMAN (1-192): 7.26e-85: 250: 91.67
+	Hs
		1015746 PAR6B_HUMAN (13-336): 7.26e-69: 222: 48.01		RHOG_HUMAN (1-192): 3.53e-78: 233: 67.19
+	Hs
		953650 PAR6B_HUMAN (13-336): 7.26e-69: 222: 48.01		RAC3_HUMAN (1-191): 4.3e-78: 233: 89.53
+	Hs
		955554 PAR6B_HUMAN (13-336): 7.26e-69: 222: 48.01		CDC42_HUMAN (1-192): 2.46e-78: 233: 69.27
+	Hs
		1418667 PAR6G_HUMAN (1-334): 5.9e-66: 214: 46.06		RHOJ_HUMAN (2-190): 4.29e-80: 239: 60.32
+	Hs
		168627 CSKP_HUMAN (29-344): 8.01e-60: 208: 16.05		RAC2_HUMAN (1-192): 3.07e-81: 241: 89.06
+	Mm
		953813 PAR6B_MOUSE (13-336): 2.48e-66: 215: 48.01		CDC42_MOUSE (1-192): 2.46e-78: 233: 69.27
+	Hs
		168748 CSKP_HUMAN (29-344): 8.01e-60: 208: 16.05		RHOJ_HUMAN (2-190): 4.29e-80: 239: 60.32
+	Hs
		601430 PAR6B_HUMAN (13-336): 7.26e-69: 222: 48.01		RHOQ_HUMAN (4-192): 1.02e-74: 225: 62.05
+	Hs
		955553 PAR6G_HUMAN (1-334): 5.9e-66: 214: 46.06		CDC42_HUMAN (1-192): 2.46e-78: 233: 69.27
+	Hs
		168664 CSKP_HUMAN (29-344): 8.01e-60: 208: 16.05		CDC42_HUMAN (1-192): 2.46e-78: 233: 69.27
+	Hs
		168672 CSKP_HUMAN (29-344): 8.01e-60: 208: 16.05		RHOG_HUMAN (1-192): 3.53e-78: 233: 67.19
+	Hs
		955370 PALS1_HUMAN (26-346): 7.08e-61: 208: 16.91		CDC42_HUMAN (1-192): 2.46e-78: 233: 69.27
+	Hs
		962263 PALS1_HUMAN (26-346): 7.08e-61: 208: 16.91		RHOA_HUMAN (5-192): 1.2e-76: 229: 54.79
+	Hs
		168631 CSKP_HUMAN (29-344): 8.01e-60: 208: 16.05		RHOQ_HUMAN (4-192): 1.02e-74: 225: 62.05
+	Ce
		1050333 PAR6_CAEEL (18-319): 2.76e-58: 192: 50.00		CDC42_CAEEL (1-192): 1.09e-75: 226: 68.75