Protein: PAR6B
Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)

Gene: PAR6B, PARD6B
Organism: Homo sapiens
Interactions: 107
UniProt ID: Q9BYG5

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005923 - bicellular tight junction
GO:0005938 - cell cortex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1051308

KPCZ
Protein kinase C zeta type

14

14

Small-scale

0.986

High

835745

KPCI
Protein kinase C iota type

14

16

Small-scale

0.985

High

955554

CDC42
Cell division control protein 42 homolog

9

20

Small-scale

0.982

High

1418672

RHOJ
Rho-related GTP-binding protein RhoJ

7

20

High-throughput

0.968

High

1353263

PARD3
Partitioning defective 3 homolog

8

20

Small-scale

0.967

High

601430

RHOQ
Rho-related GTP-binding protein RhoQ

4

20

Small-scale

0.893

High

988678

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

Small-scale

0.821

High

1418665

PAR6G
Partitioning defective 6 homolog gamma

2

12

High-throughput

0.811

High

1418678

PAR6A
Partitioning defective 6 homolog alpha

2

15

High-throughput

0.811

High

1402048

TRIB3
Tribbles homolog 3

2

3

High-throughput

0.783

High

953650

RAC3
Ras-related C3 botulinum toxin substrate 3

2

20

High-throughput

0.776

High

1241035

L2GL2
LLGL scribble cell polarity complex component 2

9

8

Small-scale

0.755

High

1146340

L2GL1
Lethal(2) giant larvae protein homolog 1

6

8

High-throughput

0.735

High

967950

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

High-throughput

0.691

High

1115603

ASPP2
Apoptosis-stimulating of p53 protein 2

1

2

High-throughput

0.691

High

1414066

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

5

High-throughput

0.691

High

1418676

ROBO2
Roundabout homolog 2

1

1

High-throughput

0.691

High

1418677

MYO10
Unconventional myosin-X

1

2

High-throughput

0.691

High

1418685

ROBO1
Roundabout homolog 1

1

1

High-throughput

0.691

High

1358847

KBTB7
Kelch repeat and BTB domain-containing protein 7

4

4

Small-scale

0.691

High

1152036

PTN14
Tyrosine-protein phosphatase non-receptor type 14

3

12

High-throughput

0.667

High

1311646

KIBRA
Protein KIBRA

3

14

High-throughput

0.667

High

1394261

GMCL1
Germ cell-less protein-like 1

3

4

High-throughput

0.654

High

1347452

CEP76
Centrosomal protein of 76 kDa

3

0

High-throughput

0.646

High

1049739

1433F
14-3-3 protein eta

2

9

High-throughput

0.628

High

1359636

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

1

Small-scale

0.621

High

401436

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.618

High

710464

EPHA2
Ephrin type-A receptor 2

1

18

High-throughput

0.618

High

962819

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

1015746

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1396621

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

1418674

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

207874

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

3

2

High-throughput

0.609

High

1163757

PTN21
Tyrosine-protein phosphatase non-receptor type 21

3

14

High-throughput

0.609

High

1212612

HECD3
E3 ubiquitin-protein ligase HECTD3

3

9

High-throughput

0.609

High

1331245

ARL10
ADP-ribosylation factor-like protein 10

3

3

High-throughput

0.609

High

1332655

ZSCA4
Zinc finger and SCAN domain-containing protein 4

2

1

High-throughput

0.606

High

1382628

MGN2
Protein mago nashi homolog 2

2

1

High-throughput

0.606

High

1398977

FRMD6
FERM domain-containing protein 6

2

18

High-throughput

0.606

High

1418683

TRI35
E3 ubiquitin-protein ligase TRIM35

2

4

High-throughput

0.606

High

242820

PRKN
E3 ubiquitin-protein ligase parkin

2

9

High-throughput

0.584

High

269367

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

1292466

RASF3
Ras association domain-containing protein 3

2

0

High-throughput

0.580

High

1417024

CDCA4
Cell division cycle-associated protein 4

2

0

High-throughput

0.580

High

1063596

GOGA2
Golgin subfamily A member 2

1

3

High-throughput

0.573

High

396874

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

1414227

CRUM3
Protein crumbs homolog 3

1

6

Small-scale

0.561

High

1340412

RASF8
Ras association domain-containing protein 8

2

2

High-throughput

0.558

High

1307784

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

0

High-throughput

0.536

High

316316

RECQ5
ATP-dependent DNA helicase Q5

1

1

High-throughput

0.536

High

485389

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.536

High

691395

1433T
14-3-3 protein theta

1

9

High-throughput

0.536

High

971961

1433E
14-3-3 protein epsilon

1

2

High-throughput

0.536

High

990692

1433Z
14-3-3 protein zeta/delta

1

9

High-throughput

0.536

High

1394190

LRCH3
DISP complex protein LRCH3

1

1

High-throughput

0.536

High

1410835

SLF1
SMC5-SMC6 complex localization factor protein 1

1

2

High-throughput

0.536

High

1415809

KIFC1
Kinesin-like protein KIFC1

1

5

High-throughput

0.536

High

1418671

E41LB
Band 4.1-like protein 4B

1

14

High-throughput

0.536

High

1418682

ICAM5
Intercellular adhesion molecule 5

1

5

High-throughput

0.536

High

1418684

DLGP4
Disks large-associated protein 4

1

8

High-throughput

0.536

High

1412019

WDR83
WD repeat domain-containing protein 83

1

2

Small-scale

0.523

High

104041

F5GZI3
Partitioning defective 3 homolog

1

20

High-throughput

0.514

High

122548

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

0

High-throughput

0.513

High

297031

CCNK
Cyclin-K

1

0

High-throughput

0.513

High

317919

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.513

High

321119

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.513

High

354172

CLPT1
Putative lipid scramblase CLPTM1

1

0

High-throughput

0.513

High

584970

GNS
N-acetylglucosamine-6-sulfatase

1

0

High-throughput

0.513

High

731957

I5P2
Type II inositol 1,4,5-trisphosphate 5-phosphatase

1

0

High-throughput

0.513

High

854479

KPB1
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform

1

0

High-throughput

0.513

High

945559

SELB
Selenocysteine-specific elongation factor

1

0

High-throughput

0.513

High

1061613

FOXM1
Forkhead box protein M1

1

0

High-throughput

0.513

High

1157419

PSMD5
26S proteasome non-ATPase regulatory subunit 5

1

0

High-throughput

0.513

High

1311167

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

High-throughput

0.513

High

1336146

MSD4
Myb/SANT-like DNA-binding domain-containing protein 4

1

0

High-throughput

0.513

High

1405941

CDCA3
Cell division cycle-associated protein 3

1

0

High-throughput

0.513

High

1418680

DMBT1
Scavenger receptor cysteine-rich domain-containing protein DMBT1

1

0

High-throughput

0.513

High

1418681

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

High-throughput

0.513

High

185991

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

423093

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

136544

GOLI4
Golgi integral membrane protein 4

1

3

High-throughput

0.489

High

1031948

NC2B
Protein Dr1

1

1

High-throughput

0.489

High

1324659

AGGF1
Angiogenic factor with G patch and FHA domains 1

1

3

High-throughput

0.489

High

1418673

IFT22
Intraflagellar transport protein 22 homolog

1

2

High-throughput

0.489

High

540657

LAMP1
Lysosome-associated membrane glycoprotein 1

1

3

High-throughput

0.479

High

614730

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

2

High-throughput

0.479

High

693079

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

1023162

RBM10
RNA-binding protein 10

1

3

High-throughput

0.479

High

1150812

SF01
Splicing factor 1

1

1

High-throughput

0.479

High

1290296

KBTB6
Kelch repeat and BTB domain-containing protein 6

1

4

High-throughput

0.479

High

1367196

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

1200445

Q53SE7
Germ cell-less homolog 1

1

4

High-throughput

0.470

High

447400

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

580689

AMPN
Aminopeptidase N

1

0

High-throughput

0.458

High

1336462

PNMA1
Paraneoplastic antigen Ma1

1

5

High-throughput

0.437

High

1332033

BANP
Protein BANP

2

0

High-throughput

0.316

High

567068

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.279

Low

1250084

TMM92
Transmembrane protein 92

1

0

High-throughput

0.279

Low

1281123

RM55
Large ribosomal subunit protein mL55

1

0

High-throughput

0.279

Low

1315479

K2013
Uncharacterized protein KIAA2013

1

0

High-throughput

0.279

Low

1333395

AVL9
Late secretory pathway protein AVL9 homolog

1

0

High-throughput

0.279

Low

1383752

EME1
Structure-specific endonuclease subunit EME1

1

0

High-throughput

0.279

Low

1395623

RN170
E3 ubiquitin-protein ligase RNF170

1

0

High-throughput

0.279

Low

1418675

DEFM
Peptide deformylase, mitochondrial

1

0

High-throughput

0.279

Low

1418679

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

1212153

ATD3C
ATPase family AAA domain-containing protein 3C

1

0

High-throughput

0.249

Low

116492

H7C0N4
Splicing factor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025