HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: GAB3 (Q8WWW8)
GRB2-associated-binding protein 3 (GRB2-associated binder 3) (Growth factor receptor bound protein 2-associated protein 3)
Gene: GAB3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18235045
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 586
+	Hs
		362414 ABL1_HUMAN (1-1130): 0: 987: 100.00		DYN3_HUMAN (2-326): 5.24e-34: 139: 11.40
+	Hs
		362149 ABL1_HUMAN (1-1130): 0: 987: 100.00		MUC1_HUMAN (130-570): 1.86e-21: 101: 7.22
+	Hs
		557406 SRC_HUMAN (13-510): 0: 547: 38.58		GAB3_HUMAN (1-586): 1.15e-111: 347: 100.00
+	Hs
		440651 FYN_HUMAN (18-510): 0: 543: 38.64		GAB3_HUMAN (1-586): 1.15e-111: 347: 100.00
+	Hs
		557534 SRC_HUMAN (13-510): 0: 547: 38.58		GAB2_HUMAN (2-585): 4.64e-76: 256: 30.59
+	Hs
		440215 LCK_HUMAN (9-508): 2.02e-177: 531: 38.49		PKHA5_HUMAN (4-580): 5.46e-78: 269: 12.05
+	Mm
		431376 SRC_MOUSE (13-510): 0: 544: 38.19		GAB1_MOUSE (1-585): 1.04e-52: 193: 27.09
+	Hs
		557285 SRC_HUMAN (13-510): 0: 547: 38.58		GAB1_HUMAN (1-585): 1.19e-51: 190: 27.91
+	Hs
		463085 YES_HUMAN (5-510): 5.81e-179: 536: 39.42		GAB1_HUMAN (1-585): 1.19e-51: 190: 27.91
+	Hs
		463129 YES_HUMAN (5-510): 5.81e-179: 536: 39.42		PKHA7_HUMAN (5-472): 1.18e-50: 190: 11.86
+	Hs
		440063 LCK_HUMAN (9-508): 2.02e-177: 531: 38.49		GAB1_HUMAN (1-585): 1.19e-51: 190: 27.91
+	Hs
		440118 LCK_HUMAN (9-508): 2.02e-177: 531: 38.49		PKHA7_HUMAN (5-472): 1.18e-50: 190: 11.86
+	Hs
		473414 HCK_HUMAN (9-508): 2.76e-174: 524: 38.79		GAB1_HUMAN (1-585): 1.19e-51: 190: 27.91
+	Hs
		440251 LCK_HUMAN (9-508): 2.02e-177: 531: 38.49		PKHA6_HUMAN (4-457): 5.54e-38: 152: 13.45
+	Hs
		440790 FYN_HUMAN (18-510): 0: 543: 38.64		DYN3_HUMAN (2-326): 5.24e-34: 139: 11.40
+	Hs
		557066 SRC_HUMAN (13-510): 0: 547: 38.58		MUC1_HUMAN (130-570): 1.86e-21: 101: 7.22
+	Hs
		439935 LCK_HUMAN (9-508): 2.02e-177: 531: 38.49		MUC1_HUMAN (130-570): 1.86e-21: 101: 7.22
+	Hs
		319045 LYN_HUMAN (9-508): 2.82e-172: 518: 36.15		K0754_HUMAN (101-559): 3.69e-14: 78.3: 10.85
+	Hs
		440126 LCK_HUMAN (9-508): 2.02e-177: 531: 38.49		MPRIP_HUMAN (8-301): 1.17e-09: 63.3: 13.71
+	Hs
		215893 LCK_HUMAN (9-508): 2.02e-177: 531: 38.49		SYNJ1_HUMAN (116-451): 9.74e-09: 60.6: 8.74