HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: S10A4 (P26447)
Protein S100-A4 (Calvasculin) (Metastasin) (Placental calcium-binding protein) (Protein Mts1) (S100 calcium-binding protein A4)
Gene: S100A4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	25402006, 24658140, 30083275, unassigned2173
Identification Methods	two hybrid, protein complementation assay, affinity chromatography technology, cross-linking study, surface plasmon resonance, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005634 - nucleus GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 101
+	Hs
		362851 EGFR_HUMAN (1-1210): 0: 1246: 100.00		S10AB_HUMAN (2-97): 1.43e-37: 123: 27.84
+	Hs
		363528 EGFR_HUMAN (1-1210): 0: 1246: 100.00		HORN_HUMAN (1-96): 4.87e-33: 122: 25.74
+	Hs
		363070 EGFR_HUMAN (1-1210): 0: 1246: 100.00		S10AA_HUMAN (1-90): 7.55e-33: 111: 36.67
+	Hs
		362598 EGFR_HUMAN (1-1210): 0: 1246: 100.00		S10A9_HUMAN (3-91): 2.19e-29: 102: 31.11
+	Hs
		362840 EGFR_HUMAN (1-1210): 0: 1246: 100.00		S10A7_HUMAN (3-93): 7.13e-20: 78.7: 23.66
+	Hs
		686814 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		S10A4_HUMAN (1-101): 5.67e-40: 129: 100.00
+	Hs
		731770 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		S10AB_HUMAN (2-97): 1.43e-37: 123: 27.84
+	Hs
		954956 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		S10AA_HUMAN (1-90): 7.55e-33: 111: 36.67
+	Hs
		410657 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		S10AB_HUMAN (2-97): 1.43e-37: 123: 27.84
+	Hs
		641487 ERBB3_HUMAN (1-1205): 0: 1102: 41.39		S10A4_HUMAN (1-101): 5.67e-40: 129: 100.00
+	Hs
		641545 ERBB3_HUMAN (1-1205): 0: 1102: 41.39		S10AA_HUMAN (1-90): 7.55e-33: 111: 36.67
+	Hs
		407578 ERBB3_HUMAN (1-1205): 0: 1102: 41.39		S100B_HUMAN (3-91): 4.85e-32: 109: 47.19
+	Hs
		410998 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		S10AG_HUMAN (3-83): 4.09e-24: 89.5: 37.81
+	Hs
		411066 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		S10AE_HUMAN (3-84): 9.42e-21: 81: 28.05
+	Hs
		444884 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		S10A9_HUMAN (3-91): 2.19e-29: 102: 31.11
+	Hs
		424126 INSRR_HUMAN (336-656): 1.4e-24: 113: 20.62		S10A8_HUMAN (1-88): 2e-25: 92.6: 29.55